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SHR Neuro Cancer Cardio Lipid Metab Microb
Beer, M; Machann, W; Sandstede, J; Buchner, S; Lipke, C; Kostler, H; Lorenz, R; Harre, K; Spindler, M; Hahn, D.
Energetic differences between viable and non-viable myocardium in patients with recent myocardial infarction are not an effect of differences in wall thinning - a multivoxel P-31-MR-spectroscopy and MRI study
Eur Radiol. 2007; 17(5):1275-1283
Doi: 10.1007/s00330-006-0492-y
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- Abstract:
- To evaluate multivoxel (31)P-MR spectroscopy (MRS) for assessment of energy metabolism in patients with myocardial infarction (MI) in correlation to left ventricular (LV) wall thickness and the outcome of revascularization. Thirty patients with subacute anterior myocardial infarction and planned revascularization were enrolled. 3D-chemical shift imaging was applied to determine PCr/ATP ratios in two areas: infarcted/anterior and noninfarcted/septal myocardium. MRI was used to evaluate LV function and wall thickness, and was repeated 6 months after revascularization to assess myocardial viability. Fifteen volunteers were controls. Fifteen patients showed normalization of wall motion abnormalities after revascularization (Group 1; viable), 15 not (Group 2; non-viable). Regarding infarcted/anterior myocardium, Group 2 had lower PCr/ATP ratios (0.81 +/- 0.60 vs 1.17 +/- 0.25), and PCr/ATP ratios were reduced in both groups compared to controls (1.45 +/- 0.29). Regarding noninfarcted/septal myocardium, again Group 2 had lower ratios (0.93 +/- 0.53 vs 1.31 +/- 0.38); however, compared to controls (1.51 +/- 0.32) a reduction of PCr/ATP ratios was only found in Group 2. For both myocardial regions, no correlations between PCr/ATP ratios and LV wall thickness were detected. The more severe energetic alteration in irreversibly damaged myocardium is not an effect of differences of wall thinning. Additional alterations of noninfarcted, adjacent myocardium can be detected.
- Find related publications in this database (using NLM MeSH Indexing)
- Adult -
- Aged -
- Case-Control Studies -
- Electrocardiography -
- Energy Metabolism -
- Female -
- Humans -
- Image Processing, Computer-Assisted -
- Imaging, Three-Dimensional -
- Magnetic Resonance Imaging - methods
- Magnetic Resonance Spectroscopy - methods
- Male -
- Middle Aged -
- Myocardial Infarction - pathology Myocardial Infarction - therapy
- Myocardium - metabolism Myocardium - pathology
- Phosphorus Isotopes - diagnostic use
- Statistics, Nonparametric -
- Ventricular Remodeling -
- Find related publications in this database (Keywords)
- myocardial infarction
- magnetic resonance spectroscopy
- magnetic resonance imaging
- myocardial revascularization
- ventricular remodeling