Medizinische Universität Graz - Research portal
Selected Publication:
SHR Neuro Cancer Cardio Lipid Metab Microb
Kostler, H; Landschutz, W; Koeppe, S; Seyfarth, T; Lipke, C; Sandstede, J; Spindler, M; von Kienlin, M; Hahn, D; Beer, M.
Age and gender dependence of human cardiac phosphorus metabolites determined by SLOOP P-31 MR spectroscopy
Magn Reson Med. 2006; 56(4):907-911
Doi: 10.1002/mrm.21027
Web of Science
PubMed
FullText
FullText_MUG
Google Scholar
- Co-authors Med Uni Graz
- Beer Meinrad
- Altmetrics:
- Dimensions Citations:
- Plum Analytics:
- Scite (citation analytics):
- Abstract:
- The aim of this study was to apply (31)P magnetic resonance spectroscopy (MRS) using spatial localization with optimal point spread function (SLOOP) to investigate possible age and gender dependencies of the energy metabolite concentrations in the human heart. Thirty healthy volunteers (18 males and 12 females, 21-67 years old, mean = 40.7 years) were examined with the use of (31)P-MRS on a 1.5 T scanner. Intra- and interobserver variability measures (determined in eight of the volunteers) were both 3.8% for phosphocreatine (PCr), and 4.7% and 8.3%, respectively, for adenosine triphosphate (ATP). High-energy phosphate (HEP) concentrations in mmol/kg wet weight were 9.7 +/- 2.4 (age < 40 years, N = 16) and 7.7 +/- 2.5 (age >or= 40 years, N = 14) for PCr, and 5.1 +/- 1.0 (age < 40 years) and 4.1 +/- 0.8 (age >or= 40 years) for ATP, respectively. Separated by gender, PCr concentrations of 9.2 +/- 2.4 (men, N = 18) and 8.0 +/- 2.8 (women, N = 12) and ATP concentrations of 4.9 +/- 1.0 (men) and 4.2 +/- 0.9 (women) were measured. A significant decrease of PCr and ATP was found for volunteers older than 40 years (P < 0.05), but the differences in metabolic concentrations between both sexes were not significant. In conclusion, age has a minor but still significant impact on cardiac energy metabolism, and no significant gender differences were detected.
- Find related publications in this database (using NLM MeSH Indexing)
- Adenosine Triphosphate - metabolism
- Adult -
- Age Factors -
- Aged -
- Energy Metabolism -
- Female -
- Humans -
- Magnetic Resonance Spectroscopy - methods
- Male -
- Middle Aged -
- Myocardium - metabolism
- Phosphates - metabolism
- Phosphocreatine - metabolism
- Phosphorus Isotopes - diagnostic use
- Sex Factors -
- Statistics, Nonparametric -
- Find related publications in this database (Keywords)
- myocardium
- aging
- cardiac energy metabolism
- P-31
- MR spectroscopy
- gender difference