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SHR Neuro Cancer Cardio Lipid Metab Microb
Kostler, H; Ritter, C; Lipp, M; Beer, M; Hahn, D; Sandstede, J.
Comparison of different contrast agents and doses for quantitative MR myocardial perfusion imaging
J Magn Reson Imaging. 2008; 28(2):382-389
Doi: 10.1002/jmri.21443
Web of Science
PubMed
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- Co-authors Med Uni Graz
- Beer Meinrad
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- Abstract:
- Purpose: To investigate three different contrast agents at different injection volumes for repetitive quantitative multislice myocardial perfusion imaging using the prebolus technique. Materials and Methods: Two consecutive prebolus perfusion measurements were performed on a 1.5T scanner using identical injection volumes for the first and second examination to test the reproducibility for possible rest and stress examination in normal volunteers. Either 1-8 mL, 1-12 mL Gd-DTPA, 1-4 mL, 1-6 mL. 1-9 mL Gd-BOPTA, or 1-4 mL. 1-6 mL gadobutrol were applied. Results: In cases where injection volumes were sufficiently small, there was no indication of significant differences in quantitative perfusion values with respect to the different contrast agents. Increasing the bolus volume improved the contrast-to-noise ratio (CNR) but led to saturation effects and underestimation of the true perfusion. The highest CNR was measured for gadobutrol (6 mL, p < 0.0005 compared to 8 mL Gd-DTPA). The smallest difference of perfusion values between the first and the second prebolus examination was found for Gd-BOPTA (p:5 0.006 compared Gd-DTPA). Conclusion: Prebolus examinations for quantitative myocardial perfusion imaging are possible with all three contrast agents for sufficient small injection volumes. GdBOPTA was found to be advantageous for a combined quantitative rest and stress examination.
- Find related publications in this database (using NLM MeSH Indexing)
- Adult -
- Chi-Square Distribution -
- Contrast Media - administration and dosage
- Coronary Circulation -
- Feasibility Studies -
- Female -
- Gadolinium DTPA - administration and dosage
- Humans -
- Magnetic Resonance Angiography - methods
- Male -
- Meglumine - administration and dosage Meglumine - analogs and derivatives
- Organometallic Compounds - administration and dosage
- Statistics, Nonparametric -
- Find related publications in this database (Keywords)
- magnetic resonance imaging : myocardial perfusion
- first pass perfusion
- MR contrast agents