Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Sereinigg, M; Stiegler, P; Puntschart, A; Seifert-Held, T; Zmugg, G; Wiederstein-Grasser, I; Marte, W; Marko, T; Bradatsch, A; Tscheliessnigg, K; Stadlbauer-Köllner, V.
Establishing a brain-death donor model in pigs.
Transplant Proc. 2012; 44(7):2185-2189
Doi: 10.1016/j.transproceed.2012.07.105
Web of Science
PubMed
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FullText_MUG
- Führende Autor*innen der Med Uni Graz
- Sereinigg Michael
- Stiegler Philipp
- Co-Autor*innen der Med Uni Graz
- Grün Andreas Jürgen
- Marko Thomas Peter
- Marte Wolfgang
- Seifert-Held Thomas
- Simon Andrea
- Stadlbauer-Köllner Vanessa
- Tscheliessnigg Karlheinz
- Wiederstein-Grasser Iris
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- Abstract:
- An animal model that imitates human conditions might be useful not only to monitor pathomechanisms of brain death and biochemical cascades but also to investigate novel strategies to ameliorate organ quality and functionality after multiorgan donation. Brain death was induced in 15 pigs by inserting a catheter into the intracranial space after trephination of the skull and augmenting intracranial pressure until brain stem herniation. Intracranial pressure was monitored continuously; after 60 minutes, brain death diagnostics were performed by a neurologist including electroencephalogram (EEG) and clinical examinations. Clinical examinations included testing of brain stem reflexes as well as apnoe testing; then intensive donor care was performed according to standard guidelines until 24 hours after confirmation of brain death. Intensive donor care was performed according to standard guidelines for 24 hours after brain death. Sixty minutes after brain-death induction, neurological examination and EEG examination confirmed brain death. Intracranial pressure increased continuously, remaining stable after the occurrence of brain death. All 15 animals showed typical signs of brain death such as diabetes insipidus, hypertensive and hypotensive periods, as well as tachycardia. All symptoms were treated with standard medications. After 24 hours of brain death we performed successful multiorgan retrieval. Brain death can be induced in a pig model by inserting a catheter after trephination of the skull. According to standard guidelines the brain-death diagnosis was established by a flat-line EEG, which occurred in all animals at 60 minutes after induction. Copyright © 2012 Elsevier Inc. All rights reserved.
- Find related publications in this database (using NLM MeSH Indexing)
- Animals -
- Brain Death -
- Models, Animal -
- Swine -
- Tissue Donors -