Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
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SHR Neuro Krebs Kardio Lipid Stoffw Microb
Schoellnast, H; Deodhar, A; Hsu, M; Moskowitz, C; Nehmeh, SA; Thornton, RH; Sofocleous, CT; Alago, W; Downey, RJ; Azzoli, CG; Rosenzweig, KE; Solomon, SB.
Recurrent non-small cell lung cancer: evaluation of CT-guided radiofrequency ablation as salvage therapy.
Acta Radiol. 2012; 53(8):893-899
Doi: 10.1258/ar.2012.110333
Web of Science
PubMed
FullText
FullText_MUG
- Führende Autor*innen der Med Uni Graz
- Schoellnast Helmut
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- Abstract:
- Background: Radiofrequency ablation (RFA) is a potential application as a salvage tool after failure of surgery, chemotherapy, or radiotherapy of non-small cell lung cancer (NSCLC). Although several studies have evaluated the use of RFA in primary NSCLC, there is little literature on its potential application as a salvage tool. Purpose: To evaluate CT-guided RFA employed as a salvage therapy for pulmonary recurrences of NSCLC after prior treatment with chemotherapy, radiation therapy, and/or surgery. Material and Methods: A retrospective computer database search yielded 33 patients with biopsy proven primary NSCLC who underwent CT-guided RFA of 39 recurrent tumors following surgery, chemotherapy, and/or radiotherapy. Follow-up imaging was performed with CT and PET-CT. The endpoints of interest were progression-free survival (PFS) and time to local progression (TTLP). PFS and TTLP were compared by lesion size (ANDlt;3 cm, ANDgt;= 3 cm). Results: The median PFS was 8 months. For patients with a tumor size ANDlt;3 cm median PFS was 11 months, whereas the median PFS of patients with a tumor size ANDgt;= 3 cm was 5 months. The difference did not reach statistical significance (P = 0.09). The median TTLP of all tumors was 14 months. TTLP of ablated tumors ANDlt;3 cm in size was 24 months, compared to 8 months for ablated tumors ANDgt;= 3 cm in size. The difference did not reach statistical significance (P = 0.07). Conclusion: RFA of recurrent NSCLC may be a valuable salvage tool to achieve local tumor control, especially in tumors measuring ANDlt;3 cm in size.
- Find related publications in this database (using NLM MeSH Indexing)
- Aged -
- Aged, 80 and over -
- Carcinoma, Non-Small-Cell Lung - mortality
- Catheter Ablation -
- Disease Progression -
- Disease-Free Survival -
- Female -
- Follow-Up Studies -
- Humans -
- Kaplan-Meier Estimate -
- Length of Stay -
- Lung Neoplasms - mortality
- Male -
- Middle Aged -
- Neoplasm Recurrence, Local - mortality
- Retrospective Studies -
- Surgery, Computer-Assisted -
- Survival Rate -
- Tomography, X-Ray Computed -
- Treatment Outcome -
- Find related publications in this database (Keywords)
- Non-small-cell lung carcinoma
- percutaneous radiofrequency ablation
- local tumor progression
- survival