Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Falcone, GJ; Biffi, A; Devan, WJ; Jagiella, JM; Schmidt, H; Kissela, B; Hansen, BM; Jimenez-Conde, J; Giralt-Steinhauer, E; Elosua, R; Cuadrado-Godia, E; Soriano, C; Ayres, AM; Schwab, K; Pera, J; Urbanik, A; Rost, NS; Goldstein, JN; Viswanathan, A; Pichler, A; Enzinger, C; Norrving, B; Tirschwell, DL; Selim, M; Brown, DL; Silliman, SL; Worrall, BB; Meschia, JF; Kidwell, CS; Montaner, J; Fernandez-Cadenas, I; Delgado, P; Broderick, JP; Greenberg, SM; Roquer, J; Lindgren, A; Slowik, A; Schmidt, R; Flaherty, ML; Kleindorfer, DO; Langefeld, CD; Woo, D; Rosand, J; on behalf of the International Stroke Genetics Consortium.
Burden of Risk Alleles for Hypertension Increases Risk of Intracerebral Hemorrhage.
Stroke. 2012; 43(11):2877-2883
Doi: 10.1161/STROKEAHA.112.659755
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- Co-Autor*innen der Med Uni Graz
- Enzinger Christian
- Pichler Alexander
- Schmidt Helena
- Schmidt Reinhold
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- Abstract:
- Background and Purpose-Genetic variation influences risk of intracerebral hemorrhage (ICH). Hypertension (HTN) is a potent risk factor for ICH and several common genetic variants (single nucleotide polymorphisms [SNPs]) associated with blood pressure levels have been identified. We sought to determine whether the cumulative burden of blood pressure-related SNPs is associated with risk of ICH and pre-ICH diagnosis of HTN. Methods-We conducted a prospective multicenter case-control study in 2272 subjects of European ancestry (1025 cases and 1247 control subjects). Thirty-nine SNPs reported to be associated with blood pressure levels were identified from the National Human Genome Research Institute genomewide association study catalog. Single-SNP association analyses were performed for the outcomes ICH and pre-ICH HTN. Subsequently, weighted and unweighted genetic risk scores were constructed using these SNPs and entered as the independent variable in logistic regression models with ICH and pre-ICH HTN as the dependent variables. Results-No single SNP was associated with either ICH or pre-ICH HTN. The blood pressure-based unweighted genetic risk score was associated with risk of ICH (OR, 1.11; 95% CI, 1.02-1.21; P=0.01) and the subset of ICH in deep regions (OR, 1.18; 95% CI, 1.07-1.30; P=0.001), but not with the subset of lobar ICH. The score was associated with a history of HTN among control subjects (OR, 1.17; 95% CI, 1.04-1.31; P=0.009) and ICH cases (OR, 1.15; 95% CI, 1.01-1.31; P=0.04). Similar results were obtained when using a weighted score. Conclusion-Increasing numbers of high blood pressure-related alleles are associated with increased risk of deep ICH as well as with clinically identified HTN. (Stroke. 2012; 43: 2877-2883.)
- Find related publications in this database (using NLM MeSH Indexing)
- Aged -
- Alleles -
- Case-Control Studies -
- Female -
- Genetic Predisposition to Disease - genetics
- Genotype -
- Humans -
- Hypertension - complications
- Intracranial Hemorrhage, Hypertensive - genetics
- Male -
- Polymorphism, Single Nucleotide -
- Risk Factors -
- Find related publications in this database (Keywords)
- genetic risk score
- genetics
- hypertension
- intracerebral hemorrhage