Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
O'Hartaigh, B; Neil Thomas, G; Silbernagel, G; Bosch, JA; Pilz, S; Loerbroks, A; Kleber, ME; Grammer, TB; Böhm, BO; März, W.
Association of 25-hydroxyvitamin D with type 2 diabetes among patients undergoing coronary angiography: cross-sectional findings from the LUdwigshafen Risk and Cardiovascular Health (LURIC) Study.
Clin Endocrinol (Oxf). 2013; 79(2):192-198
Doi: 10.1111/cen.12024
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- Co-Autor*innen der Med Uni Graz
- März Winfried
- Pilz Stefan
- Silbernagel Günther
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- Abstract:
- Evidence suggests that vitamin D may protect against the onset of diabetes. However, the mechanisms underlying the role of vitamin D on glycaemic status are unclear and warrant further investigation. We sought to determine the relationship between serum 25-hydroxyvitamin D (25[OH]D) and glycaemic status among intermediate-to-high-risk patients scheduled for coronary angiography. Participants were 3316 male and female patients (mean ± SD age, 62·7 ± 10·6 years). Four categories were formed according to serum 25[OH]D levels. The association between serum 25[OH]D and diabetes was assessed using multivariable logistic regression. Fasting and 2 h post-load glucose, HbA1c and the HOMA-IR indices diminished with increasing serum 25[OH]D levels (P < 0·001). However, no associations were observed between insulin, pro-insulin or C-peptide and serum 25[OH]D concentrations. The pro-inflammatory markers IL-6 and hs-CRP also decreased considerably with higher vitamin D levels (P < 0·001). After full adjustment, those with optimal serum 25[OH]D levels had a reduced odds for fasting diabetes (OR = 0·63; 95% CI, 0·46-0·86; Ptrend = 0·01), 2 h post-load diabetes (OR = 0·46; 95% CI, 0·29-0·74; Ptrend = 0·004), both fasting/2 h post-load diabetes (OR = 0·61; 95% CI, 0·42-0·87; Ptrend = 0·001) and all of the combined hyperglycaemic states (OR = 0·68; 95% CI, 0·52-0·80; Ptrend = 0·01). Higher serum 25[OH]D levels were associated with better glycaemic status and lower inflammation. Should these observations be confirmed in future studies, vitamin D supplementation may prove a useful adjunct in attenuating the onset of diabetes. © 2012 John Wiley & Sons Ltd.
- Find related publications in this database (using NLM MeSH Indexing)
- Adolescent -
- Adult -
- Aged -
- Aged, 80 and over -
- Blood Glucose - metabolism
- Cardiovascular Diseases - etiology
- Coronary Angiography -
- Cross-Sectional Studies -
- Diabetes Mellitus, Type 2 - blood Diabetes Mellitus, Type 2 - prevention & control
- Female -
- Female -
- Humans -
- Hyperglycemia - complications
- Inflammation - complications
- Insulin - blood
- Male -
- Middle Aged -
- Prediabetic State - blood
- Vitamin D - analogs & derivatives Vitamin D - blood
- Vitamin D Deficiency - complications