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Selected Publication:
Schmidt, HH; Sill, H; Eibl, M; Beham-Schmid, C; Höfler, G; Haas, OA; Krejs, GJ; Linkesch, W.
Hodgkin's disease developing after spontaneous remission of chronic lymphocytic leukemia.
Ann Hematol. 1995; 71(5):247-252
Doi: 10.1007/s002770050113
(- Case Report)
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- Leading authors Med Uni Graz
- Schmidt Helmut
- Co-authors Med Uni Graz
- Beham-Schmid Christine
- Eibl Margit
- Höfler Gerald
- Krejs Günter Josef
- Linkesch Werner
- Sill Heinz
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- Abstract:
- We present a 71-year-old patient with chronic lymphocytic leukemia diagnosed 27 years ago. Initially, the disease was staged as Rai II and the patient suffered from secondary immunoglobulin deficiency. Nevertheless, no treatment was necessary at that time. Because of disease progression a single course of chemotherapy was given in 1984. During the following year there was a constant decline of the WBC, accompanied by normalization of the immunoglobulins; both have remained stable ever since that time. However, there was still residual bone marrow infiltration, indicating persisting CLL. In 1993 cervical lymphadenopathy occurred with acute onset. A diagnostic lymphadenectomy revealed Hodgkin's disease of the nodular-sclerosing subtype. The patient was staged as II-III according to the Ann Arbor Classification and underwent radiation therapy. Cytogenetic examination of the bone marrow revealed a normal karyotype with an inversion of chromosome 9. This case demonstrates the rate coincidence of two lymphoproliferative disorders in the same patient. The clinical course and the immunologic findings of this patient are presented, together with a review of the literature.
- Find related publications in this database (using NLM MeSH Indexing)
- Adult -
- Bone Marrow - pathology
- Chromosome Inversion -
- Chromosomes, Human, Pair 9 -
- Female -
- Hodgkin Disease - genetics Hodgkin Disease - pathology
- Humans -
- Leukemia, Lymphocytic, Chronic, B-Cell - genetics Leukemia, Lymphocytic, Chronic, B-Cell - pathology
- Neoplasm Staging -
- Neoplasms, Second Primary -
- Remission, Spontaneous -
- Find related publications in this database (Keywords)
- CLL
- Spontaneous Remission
- Immunoglobulin Deficiency
- Secondary Neoplasia
- Hodgkins Disease