Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Roten, L; Derval, N; Sacher, F; Pascale, P; Scherr, D; Komatsu, Y; Ramoul, K; Daly, M; Denis, A; Shah, AJ; Hocini, M; Jaïs, P; Haïssaguerre, M.
Heterogeneous response of J-wave syndromes to beta-adrenergic stimulation.
Heart Rhythm. 2012; 9(12):1970-1976
Doi: 10.1016/j.hrthm.2012.08.003
Web of Science
PubMed
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FullText_MUG
- Co-Autor*innen der Med Uni Graz
- Scherr Daniel
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- Abstract:
- Inferolateral early repolarization (ER) and Brugada syndrome manifest with J waves. Isoproterenol suppresses recurrent ventricular arrhythmias while reducing J waves in both disorders. To characterize the effect of isoproterenol on J waves. We analyzed the impact of isoproterenol on J waves in 20 patients with Brugada-type electrocardiogram (Br group) and 38 patients with ER (ER group). In the ER group, J waves were present in inferior leads in 32 patients (84%) and in lateral leads in 23 patients (61%). Isoproterenol increased the heart rate by 75 beats/min in the ER group and by 71 beats/min in the Br group (P = .20). The incidences of persistent (≤ 0.05-mV decrease), decreased, and normalized J waves (residual J wave ≤ 0.05 mV) were 20%, 80%, and 0% for Br group patients and 29%, 8%, and 63% for ER group patients, respectively (P <.001). Within the ER group, inferior J waves persisted in 34% of the cases, decreased in 9%, and normalized in 56% whereas lateral J waves always normalized (P <.001). Baseline QRS width was broader in ER group patients with persistent J waves (90 ms vs 80 ms; P = .003) and was unchanged with isoproterenol (90 ms; P = .19), whereas it decreased in the remaining patients (75 ms; P <.001). J-wave syndromes have distinct regional sensitivity to beta-adrenergic stimulation. J waves may persist in a subset of patients with right precordial and inferior J waves but never in lateral location. This heterogeneous response to isoproterenol may indicate distinctive mechanisms for Brugada and ER patterns, including depolarization abnormalities or ion channel sensitivity. Copyright © 2012 Heart Rhythm Society. Published by Elsevier Inc. All rights reserved.
- Find related publications in this database (using NLM MeSH Indexing)
- Adrenergic beta-Agonists - administration & dosage
- Adult -
- Brugada Syndrome - drug therapy
- Brugada Syndrome - physiopathology
- Electrocardiography - drug effects
- Female -
- Follow-Up Studies -
- Heart Rate - drug effects
- Humans -
- Isoproterenol - administration & dosage
- Male -
- Treatment Outcome -
- Find related publications in this database (Keywords)
- Early repolarization
- Brugada syndrome
- J wave
- Beta-adrenergic stimulation
- Isoproterenol
- Signal-averaged ECG
- QRS duration