Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Musteanu, M; Blaas, L; Zenz, R; Svinka, J; Hoffmann, T; Grabner, B; Schramek, D; Kantner, HP; Müller, M; Kolbe, T; Rülicke, T; Moriggl, R; Kenner, L; Stoiber, D; Penninger, JM; Popper, H; Casanova, E; Eferl, R.
A mouse model to identify cooperating signaling pathways in cancer.
Nat Methods. 2012; 9(9):897-900
Doi: 10.1038/nmeth.2130
Web of Science
PubMed
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- Co-Autor*innen der Med Uni Graz
- Popper Helmuth
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- Abstract:
- We here establish a mouse cancer model called Multi-Hit that allows for the evaluation of oncogene cooperativities in tumor development. The model is based on the stochastic expression of oncogene combinations ('hits') that are mediated by Cre in a given tissue. Cells with cooperating hits are positively selected and give rise to tumors. We used this approach to evaluate the requirement of Ras downstream effector pathways in tumorigenesis.
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