Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Zurl, B; Stranzl, H; Winkler, P; Kapp, KS.
Quantification of contralateral breast dose and risk estimate of radiation-induced contralateral breast cancer among young women using tangential fields and different modes of breathing.
Int J Radiat Oncol Biol Phys. 2013; 85(2):500-505
Doi: 10.1016/j.ijrobp.2012.04.016
Web of Science
PubMed
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- Führende Autor*innen der Med Uni Graz
- Zurl Brigitte
- Co-Autor*innen der Med Uni Graz
- Kapp Karin S.
- Stranzl-Lawatsch Heidi
- Winkler Peter
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- Abstract:
- Whole breast irradiation with deep-inspiration breath-hold (DIBH) technique among left-sided breast cancer patients significantly reduces cardiac irradiation; however, a potential disadvantage is increased incidental irradiation of the contralateral breast. Contralateral breast dose (CBD) was calculated by comparing 400 treatment plans of 200 left-sided breast cancer patients whose tangential fields had been planned on gated and nongated CT data sets. Various anatomic and field parameters were analyzed for their impact on CBD. For a subgroup of patients (aged ≤45 years) second cancer risk in the contralateral breast (CB) was modeled by applying the linear quadratic model, compound models, and compound models considering dose-volume information (DVH). The mean CBD was significantly higher in DIBH with 0.69 Gy compared with 0.65 Gy in normal breathing (P=.01). The greatest impact on CBD was due to a shift of the inner field margin toward the CB in DIBH (mean 0.4 cm; range, 0-2), followed by field size in magnitude. Calculation with different risk models for CBC revealed values of excess relative risk/Gy ranging from 0.48-0.65 vs 0.46-0.61 for DIBH vs normal breathing, respectively. Contralateral breast dose, although within a low dose range, was mildly but significantly increased in 200 treatment plans generated under gated conditions, predominately due to a shift in the medial field margin. Risk modeling for CBC among women aged ≤45 years also pointed to a higher risk when comparing DIBH with normal breathing. This risk, however, was substantially lower in the model considering DVH information. We think that clinical decisions should not be affected by this small increase in CBD with DIBH because DIBH is effective in reducing the dose to the heart in all patients. Copyright © 2013 Elsevier Inc. All rights reserved.
- Find related publications in this database (using NLM MeSH Indexing)
- Adult -
- Age Factors -
- Aged -
- Breast - radiation effects
- Breast Neoplasms - pathology
- Breast Neoplasms - radiotherapy
- Breath Holding -
- Female -
- Heart - radiation effects
- Humans -
- Linear Models -
- Middle Aged -
- Neoplasms, Radiation-Induced - etiology
- Neoplasms, Second Primary - etiology
- Organs at Risk - radiation effects
- Radiation Dosage -
- Radiation Injuries - prevention & control
- Radiotherapy Planning, Computer-Assisted -
- Risk -