Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Holzer, LA; Holzer, G.
Collagenase Clostridum histolyticum in the management of Dupuytren's contracture.
Handchir Mikrochir Plast Chir. 2011; 43(5):269-274
Doi: 10.1055/s-0031-1286314
Web of Science
PubMed
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FullText_MUG
- Co-Autor*innen der Med Uni Graz
- Holzer Lukas
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- Abstract:
- Dupuytren's contracture is a fibroproliferate disease of the palmar aponeurosis with a formation of nodules and cords. Surgical treatment is the gold standard for Dupuytren's contracture at the moment. A short while ago Collagenase clostridium histolyticum was licensed as a non-surgical method to treat Dupuytren's contracture. Collagenase clostridium histolyticum is injected directly into the Dupuytren's cord and after 24 h the contracture is distended by manual rupturing. Collagenase clostridium histolyticum causes a depletion of collagen, however neurovascular structures are spared. 2 clinical phase III studies showed that contractures could be effectively reduced when using Collagenase clostridium histolyticum. However, there are no long-term results regarding effectiveness and side effects, or comparative studies using surgical methods. This paper presents a review of Collagenase clostridium histolyticum and its role in the management of Dupuytren's contracture. Indication, technical procedure, treatment results and complications are described.
- Find related publications in this database (using NLM MeSH Indexing)
- Animals -
- Clinical Trials, Phase III as Topic -
- Clostridium histolyticum - enzymology
- Dupuytren Contracture - blood Dupuytren Contracture - drug therapy
- Follow-Up Studies -
- Humans -
- Injections -
- Male -
- Metabolic Clearance Rate - physiology
- Microbial Collagenase - adverse effects Microbial Collagenase - pharmacokinetics Microbial Collagenase - therapeutic use
- Penile Induration - blood Penile Induration - drug therapy
- Rats -
- Recurrence -
- Retreatment -
- Find related publications in this database (Keywords)
- Dupuytren's contracture
- collagenase
- Clostridium histolyticum