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Lerchbaum, E; Schwetz, V; Giuliani, A; Pieber, TR; Obermayer-Pietsch, B.
Opposing effects of dehydroepiandrosterone sulfate and free testosterone on metabolic phenotype in women with polycystic ovary syndrome.
Fertil Steril. 2012; 98(5):1318-1325 Doi: 10.1016/j.fertnstert.2012.07.1057
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Leading authors Med Uni Graz: Lerchbaum Elisabeth
Co-authors Med Uni Graz: Giuliani Albrecht; Obermayer-Pietsch Barbara; Pieber Thomas; Theiler-Schwetz Verena
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Abstract:: Objective: To study the association of adrenal and ovarian androgen levels with metabolic parameters in a large cohort of women with polycystic ovary syndrome (PCOS). Design: Cross-sectional study. Setting: Outpatient clinic of an academic hospital. Patient(s): Six hundred twenty-two women with PCOS. Intervention(s): None. Main Outcome Measure(s): Analysis of the association of endocrine dehydroepiandrosterone sulfate (DHEAS) and free testosterone (FT) parameters with metabolic measurements. Result(s): In multivariate adjusted logistic regression analyses, the odds ratio (OR) for insulin resistance was statistically significantly higher (4.42, range: 2.26-8.67) for women with PCOS who had elevated FT levels compared with the women with normal DHEAS and FT levels (reference group). We found no statistically significant differences when women with PCOS with elevated DHEAS or a combined elevation of DHEAS and FT levels were compared with the reference group. Women with PCOS and a high DHEAS/FT ratio had a more beneficial metabolic profile compared with the women with a low DHEAS/FT ratio. In multivariate adjusted binary logistic regression analyses, we found a statistically significantly lower risk for insulin resistance in the women with PCOS in the highest DHEAS/FT-ratio quartile compared with women with PCOS in the lowest quartile (OR 0.35, range: 0.14-0.89). Conclusion(s): Our results suggest that the distinction between adrenal and ovarian hyperandrogenism is important when evaluating metabolic risk in PCOS. (Fertil Steril (R) 2012;98: 1318-25. (C)2012 by American Society for Reproductive Medicine.)
Find related publications in this database (using NLM MeSH Indexing): Adrenal Glands - metabolism; Adult -; Adult -; Biological Markers - blood; Chi-Square Distribution -; Cross-Sectional Studies -; Dehydroepiandrosterone Sulfate - blood Dehydroepiandrosterone Sulfate - metabolism; Female -; Glucose Tolerance Test -; Humans -; Hyperandrogenism - blood Hyperandrogenism - diagnosis Hyperandrogenism - metabolism; Insulin Resistance -; Linear Models -; Logistic Models -; Metabolic Diseases - blood Metabolic Diseases - diagnosis Metabolic Diseases - metabolism; Middle Aged -; Multivariate Analysis -; Odds Ratio -; Ovary - metabolism Ovary - ultrasonography; Phenotype -; Polycystic Ovary Syndrome - blood Polycystic Ovary Syndrome - diagnosis Polycystic Ovary Syndrome - metabolism; Risk Assessment -; Risk Factors -; Testosterone - blood Testosterone - metabolism; Young Adult -
Find related publications in this database (Keywords): DHEAS; free testosterone; hyperandrogenemia; metabolic disturbances; polycystic ovary syndrome