Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
Ebner, T; Moser, M; Yaman, C; Sommergruber, M; Hartl, J; Jesacher, K; Tews, G.
Prospective hatching of embryos developed from oocytes exhibiting difficult oolemma penetration during ICSI.
Hum Reprod. 2002; 17(5):1317-1320
Doi: 10.1093/humrep/17.5.1317
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- Führende Autor*innen der Med Uni Graz
- Ebner Thomas
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- Abstract:
- BACKGROUND: The hormonal milieu during ovarian stimulation is known to affect oolemma behaviour as well as zona pellucida thickness and structure. This led us to investigate whether a special subgroup of patients with oocytes where penetration of the oolemma is difficult during ICSI may benefit from assisted hatching. METHODS: A total of 77 couples (mean age: 32.9+/-4.6 years; range: 22-38) had oocytes that could hardly be penetrated by the ICSI pipette. Nineteen patients underwent two ICSI cycles, giving a total number of 96 cycles, which were randomly split into either the study group (n=52) or the non-hatching group (n=44). Hatching was done using a non-contact 1.48 mm wavelength diode laser. Implantation and pregnancy rates were recorded. RESULTS: The pregnancy rate was 36.6% (19/52) in the study group and 13.6% (6/44) in the non-hatching group (P<0.05). In addition, a higher number (P<0.05) of embryos implanted in the study group (23/106; 21.7%) than in the non-hatching group (9/92; 9.8%). CONCLUSIONS: Once oolema penetration during ICSI has proven difficult, prospective hatching of embryos considered for transfer may increase their implantation behaviour.
- Find related publications in this database (using NLM MeSH Indexing)
- Adult -
- Embryo Implantation -
- Embryo, Mammalian - physiology
- Female -
- Humans -
- Laser Therapy -
- Male -
- Pregnancy -
- Pregnancy Rate -
- Prospective Studies -
- Reproductive Techniques, Assisted -
- Sperm Injections, Intracytoplasmic -
- Zona Pellucida - physiology Zona Pellucida - radiation effects
- Find related publications in this database (Keywords)
- assisted reproductive techniques
- ICSI
- oolema penetration
- ovarian stimulation