Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
Yaman, C; Ebner, T; Sommergruber, M; Hartl, J; Pölz, W; Tews, G.
Three-dimensional endometrial volume estimation as a predictor of pituitary down-regulation in an IVF-embryo transfer programme.
Hum Reprod. 2000; 15(8):1698-1702
Doi: 10.1093/humrep/15.8.1698
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- Co-Autor*innen der Med Uni Graz
- Ebner Thomas
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- Abstract:
- To examine the role of three-dimensional (3D) volume estimation in predicting pituitary down-regulation in an IVF-embryo transfer programme, 46 women were treated with buserelin acetate for down-regulation prior to and concomitantly with ovarian stimulation. Receiver operating characteristic (ROC) curve analysis was used for statistics. The area under the curve (AUC) provides a measure to show how good (AUC close to 1) or how poor (AUC close to 0.5) a test is. If down-regulation was defined as oestradiol <40, <60 or <80 pg/ml, the AUC of 3D-ultrasound was 0.57, 0.83 and 0.97 respectively. The highest sensitivity (100%) and specificity (93.2%) of 3D-ultrasound was achieved if down-regulation was defined as oestradiol <80 pg/ml (n = 44), with an endometrial volume of 1.9 ml. If down-regulation was defined as oestradiol <60 pg/ml (n = 42) the best combination of highest sensitivity (95.2%) and specificity (75. 0%) was obtained with an endometrial volume of 1.9 ml. The comparison of 3D volume calculation with endometrial thickness measurement revealed no significant difference in predicting down-regulation. 3D volume estimation provides a new tool for diagnosing relative hypo-oestrogenism or down-regulation, but it was not superior to two-dimensional ultrasound.
- Find related publications in this database (using NLM MeSH Indexing)
- Adult -
- Area Under Curve -
- Down-Regulation -
- Embryo Transfer -
- Endometrium - ultrasonography
- Estradiol - blood
- Female -
- Fertilization in Vitro -
- Humans -
- Image Processing, Computer-Assisted - methods
- Pituitary Gland - metabolism
- ROC Curve -
- Sensitivity and Specificity -
- Find related publications in this database (Keywords)
- 3D ultrasound
- down-regulation
- endometrial volume
- hormones
- IVF