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SHR Neuro Cancer Cardio Lipid Metab Microb
Ebner, T; Shebl, O; Moser, M; Sommergruber, M; Tews, G.
Developmental fate of ovoid oocytes.
Hum Reprod. 2008; 23(1):62-66
Doi: 10.1093/humrep/dem280
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- Ebner Thomas
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- Abstract:
- BACKGROUND: Irregularities in composition, thickness and/or color of the zona pellucida may impair optimal function and result in reduced outcome. Anomalies of oocyte shape have not been investigated in detail in this respect. METHODS: Therefore, all patients attending our clinic within a period of 1 year were screened for the presence of ovoid gametes and the corresponding developmental potential was evaluated. For all elongated gametes, a roundness index (RI; length divided by width) was calculated in order to quantify shape. RESULTS: RI did not affect fertilizability (P > 0.05). The degree of dysmorphism was found to be related to cleavage pattern. The more ovoid a gamete was, the higher was the risk of the corresponding zygote not cleaving like a tetrahedron (P < 0.01). Abnormal cleavage (a rather flat array of blastomeres) was associated with delayed compaction (P < 0.01) and blastocyst formation (P < 0.001). The quality of blastocysts was not affected at any stage in ovoid concepti (P > 0.05). CONCLUSIONS: Ovoid oocytes with abnormal cleavage pattern show delayed preimplantation development, probably due to a reduced number of cell-to-cell contacts.
- Find related publications in this database (using NLM MeSH Indexing)
- Adult -
- Blastocyst - physiology
- Cell Shape -
- Cleavage Stage, Ovum -
- Embryonic Development -
- Female -
- Fertilization -
- Humans -
- Male -
- Oocytes - cytology Oocytes - physiology
- Prospective Studies -
- Risk Factors -
- Sperm Injections, Intracytoplasmic -
- Time Factors -
- Zygote - physiology
- Find related publications in this database (Keywords)
- blastocyst formation
- compaction
- ovoid shape
- roundness index
- zona pellucida