Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Resch, B; Resch, E; Freidl, T; Maurer, U; Haas, J; Müller, W.
Preterm twin and triplet pregnancies are at increased risk for the development of cystic periventricular leukomalacia.
Eur J Paediatr Neurol. 2013; 17(2):148-152
Doi: 10.1016/j.ejpn.2012.06.010
Web of Science
PubMed
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- Führende Autor*innen der Med Uni Graz
- Resch Bernhard
- Co-Autor*innen der Med Uni Graz
- Freidl Thomas
- Haas Josef
- Maurer-Fellbaum Ute
- Müller Wilhelm
- Resch-Poteralski Elisabeth
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- Abstract:
- Background: An increased risk of cerebral palsy in multiples has been reported. Aims: To determine the risk for the development of periventricular leukomalacia (PVL) of twin and triplet pregnancy. Study design: Retrospective single-centre study at a tertiary care university hospital. Subjects: Infants <= 35 weeks gestational age born between 1988 and 2008. Outcome measures: Risk of twin and triplet compared to singleton pregnancy regarding development of PVL in one offspring. Results: Of 6195 infants 117 singletons and 39 multiples were diagnosed as having cystic PVL. Perinatal data did not differ as did not ultrasonographic findings and neurologic outcome. The relative risk (RR) of a twin pregnancy resulting in at least one infant with PVL when born prior to 36 weeks was 2.181 (CI 95% 1.474-3.228, p < .0001), and 6.793 (CI 95% 2.470-13.108, p < .0001) of a triplet pregnancy. In-vitro fertilisation was present in 3% of affected twins compared to 100% in triplets (p < .001). Conclusion: We found an increased risk for PVL in preterm twin and triplet pregnancies. (C) 2012 European Paediatric Neurology Society. Published by Elsevier Ltd. All rights reserved.
- Find related publications in this database (using NLM MeSH Indexing)
- Female -
- Humans -
- Infant, Newborn -
- Infant, Premature -
- Leukomalacia, Periventricular - epidemiology
- Pregnancy -
- Pregnancy, Triplet -
- Pregnancy, Twin -
- Premature Birth -
- Retrospective Studies -
- Risk Factors -
- Triplets -
- Twins -
- Find related publications in this database (Keywords)
- Multiple pregnancy
- Neurodevelopmental outcome
- Periventricular leukomalacia
- Preterm infant
- Risk factors