Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
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Cvirn, G; Hoerl, G; Schlagenhauf, A; Tafeit, E; Brodmann, M; Juergens, G; Koestenberger, M; Gary, T.
Stent implantation in the superficial femoral artery: Short thrombelastometry-derived coagulation times identify patients with late in-stent restenosis.
Thromb Res. 2012; 130(3):485-490
Doi: 10.1016/j.thromres.2012.04.007
Web of Science
PubMed
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FullText_MUG
- Führende Autor*innen der Med Uni Graz
- Cvirn Gerhard
- Co-Autor*innen der Med Uni Graz
- Brodmann Marianne
- Gary Thomas
- Hörl Gerd
- Jürgens Günther
- Koestenberger Martin
- Schlagenhauf Axel
- Tafeit Erwin
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- Abstract:
- Introduction: The mechanisms of restenosis, the recurrence of luminal narrowing, are complex and incompletely understood to date. Thrombin, the pivotal enzyme in haemostasis, presumably contributes to the formation of in-stent restenosis (ISR). It was therefore the aim of our study to investigate whether blood coagulation/thrombin generation plays a critical role in the formation of ISR in peripheral artery disease patients with stent angioplasty in the superficial femoral artery. Materials and Methods: We aimed to examine in this retrospective study whether patients with high-degree restenosis (50-75% lumen diameter reduction, n = 20) are in a hypercoaguable state implying enhanced readiness to generate thrombin compared to patients with low-degree restenosis (<50% lumen diameter reduction, n = 14). Results: The coagulation tests calibrated automated thrombography, activated partial thromboplastin time, platelet aggregation, platelet adhesion, fibrinogen, and microparticles' procoagulant activity did not indicate a different coagulation status in the two patient groups. However, the thrombelastometry-derived value Coagulation Time(CT) was significantly shorter in the high-degree restenosis group (p = 0.012), indicating a hypercoagulable state of patients with high-degree restenosis. Under our experimental conditions, CTs shorter than 444.5 s identify patients at high risk (sensitivity = 95%) for luminal narrowing. Conclusions: Our study supports the assumption that blood coagulation/thrombin generation plays a critical role in the development of ISR in peripheral arteries after stent insertion and that the thrombelastometry-derived CT might be a suitable value to identify peripheral artery disease patients at risk for development of high-degree in-stent restenosis in the superficial femoral artery. (C) 2012 Elsevier Ltd. All rights reserved.
- Find related publications in this database (using NLM MeSH Indexing)
- Aged -
- Female -
- Femoral Artery - surgery
- Graft Occlusion, Vascular - blood
- Humans -
- Male -
- Peripheral Arterial Disease - blood
- Reproducibility of Results -
- Sensitivity and Specificity -
- Stents - adverse effects
- Thrombelastography -
- Treatment Outcome -
- Whole Blood Coagulation Time -
- Find related publications in this database (Keywords)
- Coagulation
- In-stent restenosis
- Superficial femoral artery
- Thrombelastometry
- Thrombin generation