Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Xylinas, E; Rink, M; Cha, EK; Clozel, T; Lee, RK; Fajkovic, H; Comploj, E; Novara, G; Margulis, V; Raman, JD; Lotan, Y; Kassouf, W; Fritsche, HM; Weizer, A; Martinez-Salamanca, JI; Matsumoto, K; Zigeuner, R; Pycha, A; Scherr, DS; Seitz, C; Walton, T; Trinh, QD; Karakiewicz, PI; Matin, S; Montorsi, F; Zerbib, M; Shariat, SF; Upper Tract Urothelial Carcinoma Collaboration.
Impact of distal ureter management on oncologic outcomes following radical nephroureterectomy for upper tract urothelial carcinoma.
Eur Urol. 2014; 65(1):210-217
Doi: 10.1016/j.eururo.2012.04.052
Web of Science
PubMed
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- Co-Autor*innen der Med Uni Graz
- Zigeuner Richard
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- Abstract:
- There is a lack of consensus regarding the optimal approach to the bladder cuff during radical nephroureterectomy (RNU) for upper tract urothelial carcinoma (UTUC). To compare the oncologic outcomes following RNU using three different methods of bladder cuff management. Retrospective analysis of 2681 patients treated with RNU for UTUC at 24 international institutions from 1987 to 2007. Three methods of bladder cuff excision were performed: transvesical, extravesical, and endoscopic. Univariable and multivariable models tested the effect of distal ureter management on intravesical recurrence, recurrence-free survival (RFS), cancer-specific survival (CSS), and overall survival (OS). Of the 2681 patients, 1811 (67.5%) underwent the transvesical approach; 785 (29.3%), the extravesical approach; and 85 (3.2%), the endoscopic approach. There was no difference in terms of RFS, CSS, and OS among the three distal ureteral management approaches. Patients who underwent the endoscopic approach were at significantly higher risk of intravesical recurrence compared with those who underwent the transvesical (p=0.02) or extravesical approaches (p=0.02); the latter two groups did not differ from each other (p=0.40). Actuarial intravesical RFS estimates at 2 and 5 yr after RNU were 69% and 58%, 69% and 51%, and 61% and 42% for the transvesical, extravesical, and endoscopic approaches, respectively. In multivariate analyses, distal ureteral management (p=0.01), surgical technique (open vs laparoscopic; p=0.02), previous bladder cancer (p<0.001), higher tumor stage (trend; p=0.01), concomitant carcinoma in situ (CIS) (p<0.001), and lymph node involvement (trend; p<0.001) were all associated with intravesical recurrence. Excluding patients with history of previous bladder cancer, all variables remained independent predictors of intravesical recurrence. The endoscopic approach was associated with higher intravesical recurrence rates. Interestingly, concomitant CIS in the upper tract is a strong predictor of intravesical recurrence after RNU. The association of laparoscopic RNU with intravesical recurrence needs to be further investigated. Copyright © 2012 European Association of Urology. Published by Elsevier B.V. All rights reserved.
- Find related publications in this database (using NLM MeSH Indexing)
- Aged -
- Aged, 80 and over -
- Carcinoma, Transitional Cell - surgery
- Female -
- Humans -
- Kidney Neoplasms - surgery
- Male -
- Middle Aged -
- Nephrectomy -
- Retrospective Studies -
- Treatment Outcome -
- Ureter - surgery
- Ureteral Neoplasms - surgery
- Find related publications in this database (Keywords)
- Upper tract urothelial carcinoma
- Radical nephroureterectomy
- Distal ureter management
- Recurrence