Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Lerchbaum, E; Schwetz, V; Pilz, S; Grammer, TB; Look, M; Boehm, BO; Obermayer-Pietsch, B; März, W.
Association of bone turnover markers with mortality in men referred to coronary angiography.
Osteoporos Int. 2013; 24(4):1321-1332
Doi: 10.1007/s00198-012-2076-9
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PubMed
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- Führende Autor*innen der Med Uni Graz
- Lerchbaum Elisabeth
- Theiler-Schwetz Verena
- Co-Autor*innen der Med Uni Graz
- März Winfried
- Obermayer-Pietsch Barbara
- Pilz Stefan
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- Abstract:
- We aimed to examine the association of fatal events with osteocalcin (OC) and beta-crosslaps (beta-CTX) levels in men. We observed a U-shaped association of OC and beta-CTX levels with fatal events in a large cohort of men at high cardiovascular risk. Accumulating evidence suggests an association of low OC levels with metabolic disturbances. Whether OC levels are related to fatal events is, however, less clear. Further, high beta-CTX levels are linked to increased mortality. We aimed to examine the association of fatal events with both OC and beta-CTX in men. We measured OC and beta-CTX in 2,271 men referred to coronary angiography (1997-2000). We observed a U-shaped association of OC and beta-CTX with fatal events. Crude hazard ratios (HRs) for all-cause and non-cardiovascular mortality in the highest OC quintile were 1.38 (1.04-1.83) and 1.47 (0.89-2.40), respectively, and 2.11 (1.61-2.75) and 2.06 (1.29-3.29) for men in the lowest compared to the third OC quintile. In multivariate-adjusted models, HRs for all-cause, and non-cardiovascular mortality in the lowest OC quintile were 1.63 (1.23-2.16) and 1.79 (1.10-2.92), respectively, compared to the third OC quintile, whereas the association of high OC with mortality lost its significance. Crude and multivariate-adjusted HRs for cardiovascular mortality in the lowest OC quintile compared to the third OC quintile were 2.08 (1.49-2.90) and 1.74 (1.24-2.46), respectively. Moreover, high as well as low beta-CTX levels were independently associated with all-cause (quintile 1 vs. quintile 3: HR 1.42 (1.05-1.92); quintile 5 vs. quintile 3: HR 1.79 (1.31-2.45)) and cardiovascular mortality (quintile 1 vs. quintile 3: HR 1.55 (1.05-2.28); quintile 5 vs. quintile 3: HR 1.85 (1.23-2.77)). We observed a U-shaped association of OC and beta-CTX with fatal events in a large cohort of men at high cardiovascular risk.
- Find related publications in this database (using NLM MeSH Indexing)
- Aged -
- Biological Markers - blood
- Bone Remodeling - physiology
- Cardiovascular Diseases - blood Cardiovascular Diseases - mortality Cardiovascular Diseases - physiopathology Cardiovascular Diseases - radiography
- Collagen - blood
- Coronary Angiography -
- Follow-Up Studies -
- Follow-Up Studies - epidemiology
- Humans -
- Male -
- Middle Aged -
- Mortality -
- Osteocalcin - blood
- Peptide Fragments - blood
- Prognosis -
- Prospective Studies -
- Find related publications in this database (Keywords)
- Beta-crosslaps
- Bone-turnover
- Cardiovascular disease
- Mortality
- Osteocalcin