Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Lackner, H; Strenger, V; Sovinz, P; Beham-Schmid, C; Pilhatsch, A; Benesch, M; Schwinger, W; Ulreich, R; Schmidt, S; Urban, C.
Bone marrow necrosis in a girl with Hodgkin's disease.
Support Care Cancer. 2012; 20(9):2231-2234
Doi: 10.1007/s00520-012-1502-z
(- Case Report)
Web of Science
PubMed
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- Führende Autor*innen der Med Uni Graz
- Lackner Herwig
- Strenger Volker
- Co-Autor*innen der Med Uni Graz
- Beham-Schmid Christine
- Benesch Martin
- Ritter-Sovinz Petra
- Schwinger Wolfgang
- Ulreich Raphael
- Urban Ernst-Christian
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- Abstract:
- Bone marrow necrosis (BMN) is a rare finding in children with malignancy occurring most commonly in children with acute lymphoblastic leukemia. This article describes the first case of a girl who developed BMN during treatment for Hodgkin's disease. During the second cycle of chemotherapy, she experienced sudden profound bone pain in the lumbosacral region associated with elevated levels of lactate dehydrogenase (LDH), fibrin degradation products (D-Dimer), and alkaline phosphatase as well as pancytopenia and leukoerythroblastosis. MRI studies showed multiple confluent areas with low signal intensity and rim contrast enhancement in all vertebral bodies. Bone marrow biopsy revealed focal necrosis within hypocellular bone marrow. The patient responded quickly to symptomatic treatment with analgetics and heparin; however, elevations of LDH and D-Dimer persisted for 1.5 and 8 months, respectively. Clinicians should be aware of this rare condition to establish the diagnosis and to continue oncologic treatment as early as possible.
- Find related publications in this database (using NLM MeSH Indexing)
- Adolescent -
- Adolescent -
- Biological Markers - blood
- Bone Marrow - pathology
- Female -
- Hodgkin Disease - drug therapy
- Humans -
- Lumbosacral Region -
- Osteonecrosis - diagnosis Osteonecrosis - pathology
- Pancytopenia -
- Find related publications in this database (Keywords)
- bone marrownecrosis
- avascular osteonecrosis
- pancytopenia