Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Schmidt, H; Freudenberger, P; Seiler, S; Schmidt, R.
Genetics of subcortical vascular dementia.
Exp Gerontol. 2012; 47(11):873-877
Doi: 10.1016/j.exger.2012.06.003
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- Führende Autor*innen der Med Uni Graz
- Schmidt Helena
- Co-Autor*innen der Med Uni Graz
- Freudenberger Paul
- Schmidt Reinhold
- Seiler Stephan
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- Abstract:
- Subcortical vascular dementia or cerebral small vessel disease is a common cause of disability in the elderly. On magnetic resonance imaging the disease is manifested as white matter lesions, lacunes and microbleeds. Its etiology is complex, with age and hypertension as established risk factors. The heritability of white matter lesions is constantly high over different populations. Linkage studies identified several loci for these lesions however no genes responsible for the linkage signals had been identified so far. Results from genetic association studies using the candidate gene approach support the role of APOE, the renin-angiotensin system, as well as the Notch3 signaling pathway in the development of subcortical vascular dementia. The recent genomegenome wide association study on white matter lesions identified a novel locus on chromosome 17q25 harboring several genes such as TRIM65 and TRIM47 which pinpoints to possible novel mechanisms leading to these lesions.
- Find related publications in this database (using NLM MeSH Indexing)
- Adaptor Proteins, Signal Transducing - genetics
- Age Factors -
- Aged -
- Aged, 80 and over -
- Apolipoproteins E - genetics
- Chromosomes, Human, Pair 17 -
- Dementia, Vascular - etiology
- Genetic Linkage -
- Genetic Predisposition to Disease -
- Genome-Wide Association Study -
- Humans -
- Hypertension - complications
- Magnetic Resonance Imaging -
- Membrane Proteins - genetics
- Receptors, Notch - genetics
- Renin-Angiotensin System - genetics
- Risk Factors -
- Signal Transduction -
- Find related publications in this database (Keywords)
- Subcortical vascular dementia cerebral small vessel disease
- Genetics
- White matter lesions
- Lacunes
- Microbleeds
- Risk factors