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Pistracher, K; Gellner, V; Riegler, S; Schökler, B; Scarpatetti, M; Kurschel, S.
Cerebral haemorrhage in the presence of primary childhood central nervous system vasculitis-a review.
Childs Nerv Syst. 2012; 28(8):1141-1148
Doi: 10.1007/s00381-012-1827-4
Web of Science
PubMed
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- Leading authors Med Uni Graz
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Kurschel-Lackner Senta
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Pistracher Karin Felicitas
- Co-authors Med Uni Graz
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Gellner Verena
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Riegler Stefan
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Scarpatetti Michael
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- Abstract:
- The aim of the study was to evaluate frequency and clinical relevance of haemorrhagic events associated with primary angiitis of the central nervous system in childhood (cPACNS), a rare but increasingly recognized disease with varying clinical presentations. A systematic literature review from 1990 onwards was conducted to identify reported cases of cPACNS. A total of 110 paediatric patients met the inclusion criteria. The median age was 9.5 years. Seven children (7/110, 6.4 %) demonstrated cerebral haemorrhage. Death occurred only in children with cerebral haemorrhage (4/110, 3.6 %); both a sudden and prolonged course of disease was observed. PACNS is a rare disease and the occurrence of haemorrhage with this condition is even rarer; however, the risk of an unfavourable outcome under these circumstances seems to be increased. PACNS adds to the list of differential diagnoses of intracerebral haemorrhage in the paediatric population.
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Cerebral Hemorrhage - epidemiology Cerebral Hemorrhage - etiology Cerebral Hemorrhage - therapy
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Child -
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Humans -
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Risk Factors -
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Treatment Outcome -
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Vasculitis, Central Nervous System - complications
- Find related publications in this database (Keywords)
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Haemorrhage
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Central nervous system vasculitis
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Angiitis
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Small vessel disease
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Paediatrics