Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Hochrainer, K; Mayer, H; Baranyi, U; Binder, B; Lipp, J; Kroismayr, R.
The human HERC family of ubiquitin ligases: novel members, genomic organization, expression profiling, and evolutionary aspects.
Genomics. 2005; 85(2):153-164
Doi: 10.1016/j.ygeno.2004.10.006
Web of Science
PubMed
FullText
FullText_MUG
- Co-Autor*innen der Med Uni Graz
- Baranyi Ulrike
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- Abstract:
- The HERC family of ubiquitin ligases is characterized by the presence of a HECT domain and one or more RCC1-like domains. We report the identification of two novel members, HERC4 and HERC6, and subdivide the family into one group of two large and one group of four small members according to protein size and domain structure. The small members share a similar genomic organization, three of them mapping to chromosomal region 4q22, indicating strong evolutionary cohesions. Phylogenetic analysis reveals that the HERC ancestor emerged in nematodes and that the family expanded throughout evolution. The mRNA expression pattern of the small human members was found to be diverse in selected tissues and cells; overexpressed proteins display a similar cytosolic distribution. These data indicate that the HERC family members exhibit similarities in many aspects, but also sufficient differences indicating functional diversity.
- Find related publications in this database (using NLM MeSH Indexing)
- Alternative Splicing -
- Amino Acid Sequence -
- Chromosome Mapping -
- Chromosomes, Human, Pair 4 -
- Cloning, Molecular -
- Cytosol - metabolism
- Evolution, Molecular -
- Gene Expression Profiling -
- Humans -
- Molecular Sequence Data -
- Multigene Family -
- Phylogeny -
- Protein Structure, Tertiary -
- Proteins - metabolism
- Sequence Homology, Amino Acid -
- Ubiquitin-Protein Ligases - genetics Ubiquitin-Protein Ligases - metabolism
- Find related publications in this database (Keywords)
- ubiquitin ligase
- HERC
- HECT
- RCC1
- alternative splicing
- evolution