Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Baranyi, U; Pilat, N; Gattringer, M; Wekerle, T.
A chimerism-based approach to induce tolerance in IgE-mediated allergy.
Crit Rev Immunol. 2009; 29(5):379-397
Doi: 10.1615/CritRevImmunol.v29.i5.20
Web of Science
PubMed
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- Führende Autor*innen der Med Uni Graz
- Baranyi Ulrike
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- Abstract:
- Immunoglobulin-E-mediated allergy (type I allergy) is a T-helper-2-mediated disease with increasing prevalence in industrialized countries. Immunotherapy is available as causative treatment, but an effective preventive strategy is still an unmet need. Molecular chimerism is an attractive experimental approach that induces tolerance through transplantation of autologous hematopoietic stem cells that are genetically modified to express the disease-causing antigen(s). Molecular chimerism leads to permanent and robust tolerance in experimental models of autoimmune diseases and organ transplantation. Recently, proof-of-principle studies demonstrated that a type I allergic immune response can be durably tolerized by transplantation of allergen-expressing syngeneic bone marrow. We review the concept of tolerance induction through chimerism and discuss the potential of this strategy in immunoglobulin-E-mediated allergy.
- Find related publications in this database (using NLM MeSH Indexing)
- Animals -
- Autoimmune Diseases - immunology
- Chimerism -
- Humans -
- Hypersensitivity - immunology
- Immune Tolerance -
- Immunoglobulin E - immunology
- Find related publications in this database (Keywords)
- molecular chimerism
- immunological tolerance
- IgE-mediated allergy