Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Hochrainer, K; Kroismayr, R; Baranyi, U; Binder, BR; Lipp, J.
Highly homologous HERC proteins localize to endosomes and exhibit specific interactions with hPLIC and Nm23B.
Cell Mol Life Sci. 2008; 65(13):2105-2117
Doi: 10.1007/s00018-008-8148-5
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PubMed
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- Co-Autor*innen der Med Uni Graz
- Baranyi Ulrike
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- Abstract:
- Small HERC proteins are defined by the presence of one RCC1-like domain and a HECT domain. Having evolved out of one common ancestor, the four members of the family exhibit a high degree of homology in genomic organization and amino acid sequence, thus it seems possible that they might accomplish similar functions. Here we show that small HERC proteins interact with each other and localize to the same cellular structures, which we identify as late endosomes and lysosomes. We demonstrate interaction of HERC3 with the ubiquitin-like proteins hPLIC-1 and hPLIC-2 and we establish interaction of HERC5 with the metastasis suppressor Nm23B. While hPLIC proteins are not ubiquitinated by HERC3, HERC5 plays an important role in ubiquitination of Nm23B. In summary, although small HERC proteins are highly homologous showing the same subcellular distribution, they undergo different molecular interactions.
- Find related publications in this database (using NLM MeSH Indexing)
- Binding Sites -
- Carrier Proteins - genetics Carrier Proteins - metabolism
- Cell Cycle Proteins - genetics Cell Cycle Proteins - metabolism
- Cell Line -
- DNA-Binding Proteins - genetics DNA-Binding Proteins - metabolism
- Endosomes - metabolism
- HeLa Cells -
- Humans -
- Intracellular Signaling Peptides and Proteins - genetics Intracellular Signaling Peptides and Proteins - metabolism
- NM23 Nucleoside Diphosphate Kinases - genetics NM23 Nucleoside Diphosphate Kinases - metabolism
- Protein Interaction Mapping -
- Recombinant Proteins - genetics Recombinant Proteins - metabolism
- Transfection -
- Ubiquitin-Protein Ligases - genetics Ubiquitin-Protein Ligases - metabolism
- Ubiquitination -
- Ubiquitins - genetics Ubiquitins - metabolism
- Find related publications in this database (Keywords)
- ubiquitin ligase
- HERC
- homology
- endosome
- hPLIC
- Nm23B