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Tomaschitz, A; Ritz, E; Kienreich, K; Pieske, B; März, W; Boehm, BO; Drechsler, C; Meinitzer, A; Pilz, S.
Circulating Dopamine and C-Peptide Levels in Fasting Nondiabetic Hypertensive Patients: The Graz Endocrine Causes of Hypertension Study.
Diabetes Care. 2012; 35(8):1771-1773 Doi: 10.2337/dc11-2384 [OPEN ACCESS]
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Leading authors Med Uni Graz: Pilz Stefan; Tomaschitz Andreas
Co-authors Med Uni Graz: Kienreich Katharina; März Winfried; Meinitzer Andreas; Pieske Burkert Mathias
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Abstract:: OBJECTIVE-Accumulating evidence supports a potential role for dopamine in the regulation of insulin secretion. We examined the association between circulating dopamine and C-peptide concentrations using data from the Graz Endocrine Causes of Hypertension (GECOH) study. RESEARCH DESIGN AND METHODS-After 12 h of fasting, we measured plasma dopamine and serum C-peptide levels and established determining factors of insulin secretion in 201 nondiabetic hypertensive patients (mean age 48.1 +/- 16.0 years; 61.7% women). RESULTS-Mean dopamine and C-peptide concentration were 33.4 +/- 38.6 pg/mL and 3.1 +/- 2.7 ng/mL, respectively. A strong and inverse correlation was observed between dopamine and C-peptide levels (r = -0.423, P < 0.001). There was no significant relationship between C-peptide, plasma epinephrine, and norepinephrine. C-peptide levels decreased steadily and significantly from tertile 1 of dopamine (3.6 ng/mL [95% Cl 2.9-4.1]) to tertile 3 (1.6 ng/mL [1.5-2.7], P < 0.001) after multivariate adjustment. CONCLUSIONS-The inverse association between dopamine and C-pepticle highlights the need to evaluate whether dopamine could be effective for modulating endocrine pancreatic function.
Find related publications in this database (using NLM MeSH Indexing): Adult -; C-Peptide - blood; Dopamine - blood; Fasting - blood; Female -; Humans -; Hypertension - blood; Male -; Middle Aged -