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Kurschel, S; Petru, E; Luschin, G; Pickel, H.
High-Risk Metastatic Choriocarcinoma - Are 2 Additional Chemotherapy Courses After a Complete Beta-hCG-Titer Remission Sufficient - A Case-Report
GEBURTSH FRAUENHEILK 1998 58: 51-53. Doi: 10.1055/s-2007-1022120
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Leading authors Med Uni Graz: Kurschel-Lackner Senta; Petru Edgar
Co-authors Med Uni Graz: Luschin-Ebengreuth Gero
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Abstract:: The case of a 40-year old patient is described who suffered from a high-risk metastatic choriocarcinoma that developed two years after a term delivery. Initially, combination chemotherapy with the EMACO regimen (etoposide, methotrexate, actinomycin D, vincristine, cyclophosphamide) led to a complete remission. After three consecutive normal HCG levels had been determined at weekly intervals, two additional chemotherapy courses were administered. Four months later, the patient developed a recurrence based on the rise of HCG and a lesion found in the computed tomography scan of the thorax. Second-line chemotherapy with cisplatin and etoposide was initiated. After one course the patient refused further therapy. She died of pulmonary tumour progression four months later. The role and optimal number of chemotherapy courses after complete beta-HCG remission is discussed.