Medizinische Universität Graz - Research portal
Selected Publication:
Berg, J; Lötscher, E; Steimer, KS; Capon, DJ; Baenziger, J; Jäck, HM; Wabl, M.
Bispecific antibodies that mediate killing of cells infected with human immunodeficiency virus of any strain.
Proc Natl Acad Sci U S A. 1991; 88(11):4723-4727
Doi: 10.1073/pnas.88.11.4723
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- Leading authors Med Uni Graz
- Berg Jörg
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- Abstract:
- Although AIDS patients lose human immunodeficiency virus (HIV)-specific cytotoxic T cells, their remaining CD8-positive T lymphocytes maintain cytotoxic function. To exploit this fact we have constructed bispecific antibodies that direct cytotoxic T lymphocytes of any specificity to cells that express gp120 of HIV. These bispecific antibodies comprise one heavy/light chain pair from an antibody to CD3, linked to a heavy chain whose variable region has been replaced with sequences from CD4 plus a second light chain. CD3 is part of the antigen receptor on T cells and is responsible for signal transduction. In the presence of these bispecific antibodies, T cells of irrelevant specificity effectively lyse HIV-infected cells in vitro.
- Find related publications in this database (using NLM MeSH Indexing)
- Acquired Immunodeficiency Syndrome - immunology
- Antigens, CD - immunology
- Antigens, CD4 - genetics Antigens, CD4 - immunology
- Antigens, CD8 -
- Antigens, Differentiation, T-Lymphocyte - immunology
- Cell Line -
- Cytotoxicity, Immunologic -
- Fluorescent Antibody Technique -
- HIV - immunology
- HIV Antibodies - immunology
- HeLa Cells - immunology
- Humans -
- Plasmids -
- T-Lymphocytes, Cytotoxic - immunology
- Transfection -
- Find related publications in this database (Keywords)
- CD4
- ANTIBODY TO CD3
- CYTOTOXIC T-CELLS
- HUMAN IMMUNODEFICIENCY VIRUS-INFECTED HELA CELLS