Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Pichler, M; Hutterer, GC; Chromecki, TF; Jesche, J; Kampel-Kettner, K; Eberhard, K; Hoefler, G; Pummer, K; Zigeuner, R.
Trends of stage, grade, histology and tumour necrosis in renal cell carcinoma in a European centre surgical series from 1984 to 2010.
J Clin Pathol. 2012; 65(8):721-724
Doi: 10.1136/jclinpath-2012-200797
Web of Science
PubMed
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- Führende Autor*innen der Med Uni Graz
- Pichler Martin
- Co-Autor*innen der Med Uni Graz
- Chromecki Thomas
- Eberhard Katharina
- Höfler Gerald
- Hutterer Georg
- Jesche-Chromecki Johanna
- Pummer Karl
- Strini Karin
- Zigeuner Richard
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- Abstract:
- To analyse renal cell carcinoma (RCC) stage, grade, histology and necrosis migration in a large European centre series over the last 27 years. The pathology reports of 2739 consecutive patients with RCC who underwent nephrectomy from 1984 to 2010 at the institution of the authors were systematically re-evaluated. Patients were pooled into five time groups according to the date of surgery: group 1: 1984-1989, group 2: 1990-1994, group 3: 1995-1999, group 4: 2000-2004 and group 5: 2005-2010, respectively. Changes in pT categories according to WHO 2010 classification, tumour grade, histological subtype and presence of tumour necrosis (TN) were evaluated. Small pT1a tumours were found in 62/485 (12.8%) and 312/639 (48.8%) patients in groups 1 and 5, respectively (p<0.001). Advanced tumour stages (pT3a-4) were found in 306/485 (63.1%) and 171/639 (26.8%) patients in groups 1 and 5, respectively (p<0.001). The number of grade 3/4 tumours increased from 62/485 (12.7%) and 130/639 (20.3%) in groups 1 and 5, respectively, whereas the number of grade 1 tumours decreased over time (p<0.001). There has been a significant histological migration for the chromophobe subtype from 1.1% to 4.3% (p=0.002). The frequency of the presence TN decreased from 41.7% in group 1 to 32.7% in group 5 (p<0.001). In contrast to data from Australia but similar to data from US cohorts, a statistically significant stage migration towards small RCCs was observed in this European cohort. Significant changes in tumour grade, histological subtype and TN were also observed.
- Find related publications in this database (using NLM MeSH Indexing)
- - epidemiology
- Carcinoma, Renal Cell - epidemiology
- Carcinoma, Renal Cell - pathology
- Carcinoma, Renal Cell - surgery
- Chi-Square Distribution -
- Humans -
- Kidney Neoplasms - epidemiology
- Kidney Neoplasms - pathology
- Kidney Neoplasms - surgery
- Necrosis -
- Neoplasm Grading -
- Neoplasm Staging -
- Nephrectomy -
- Retrospective Studies -
- Time Factors -