Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Silbernagel, G; Rosinger, S; Grammer, TB; Kleber, ME; Winkelmann, BR; Boehm, BO; März, W.
Duration of type 2 diabetes strongly predicts all-cause and cardiovascular mortality in people referred for coronary angiography.
Atherosclerosis. 2012; 221(2):551-557
Doi: 10.1016/j.atherosclerosis.2012.01.011
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- Führende Autor*innen der Med Uni Graz
- März Winfried
- Silbernagel Günther
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- Abstract:
- Type 2 diabetes represents a major cardiovascular risk factor. However, few studies have addressed the impact of the disease duration on mortality. Thus, we aimed to investigate the predictive value of diabetes duration for all-cause and cardiovascular mortality in subjects undergoing coronary angiography. We studied 2455 participants of the LUdwigshafen RIsk and Cardiovascular health study (1768 males/687 females). They had a mean ± standard deviation (SD) age of 63.1 ± 9.0 years (range: 40.0-79.9) and a mean ± SD body mass index of 27.7 ± 4.0 kg/m(2). 704 subjects were newly diagnosed with type 2 diabetes according to the 2010 criteria of the American Diabetes Association and 446 subjects had a known history of type 2 diabetes. The mean ± SD duration of the follow-up for all-cause and cardiovascular mortality was 7.4 ± 2.3 years. A total of 543 deaths occurred during the follow-up. Among these, 343 were accounted for by cardiovascular diseases. The duration of type 2 diabetes was strongly and positively correlated with all-cause and cardiovascular mortality (both P<0.001). The multivariate adjusted hazard ratios (95% confidence intervals) for cardiovascular mortality compared to subjects without diabetes were 1.76 (1.34-2.32), 2.86 (2.00-4.08), 2.96 (1.85-4.74), and 4.55 (3.24-6.39) for subjects with new onset type 2 diabetes and subjects with known type 2 diabetes (duration ≤ 5, >5 and ≤ 10, >10 years), respectively. The data emphasise the need to consider the diabetes duration for the prediction of mortality in subjects at intermediate to high cardiovascular risk. Copyright © 2012 Elsevier Ireland Ltd. All rights reserved.
- Find related publications in this database (using NLM MeSH Indexing)
- Adult -
- Aged -
- Cause of Death -
- Chi-Square Distribution -
- Coronary Angiography -
- Coronary Artery Disease - mortality Coronary Artery Disease - prevention & control Coronary Artery Disease - radiography
- Diabetes Complications - mortality Diabetes Complications - prevention & control Diabetes Complications - radiography
- Diabetes Mellitus, Type 2 - diagnosis Diabetes Mellitus, Type 2 - mortality Diabetes Mellitus, Type 2 - therapy
- Female -
- Female -
- Humans -
- Male -
- Middle Aged -
- Multivariate Analysis -
- Predictive Value of Tests -
- Prognosis -
- Proportional Hazards Models -
- Referral and Consultation -
- Risk Assessment -
- Risk Factors -
- Survival Analysis -
- Time Factors -
- Find related publications in this database (Keywords)
- Duration of type 2 diabetes
- All-cause mortality
- Cardiovascular mortality