Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Betge, J; Schneider, NI; Pollheimer, MJ; Lindtner, RA; Kornprat, P; Schlemmer, A; Rehak, P; Langner, C.
Is there a rationale to record lymphatic invasion in node-positive colorectal cancer?
J Clin Pathol. 2012; 65(9):847-850
Doi: 10.1136/jclinpath-2012-200817
Web of Science
PubMed
FullText
FullText_MUG
- Führende Autor*innen der Med Uni Graz
- Langner Cord
- Co-Autor*innen der Med Uni Graz
- Kornprat Peter
- Pollheimer Marion
- Rehak Peter
- Schlemmer Andrea
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- Abstract:
- This study aimed to evaluate the prognostic significance of lymphatic invasion in colorectal cancers that have already spread to regional lymph nodes. 168 patients with node-positive tumours (colon, n=98; rectum, n=70) were retrospectively evaluated. Lymphatic invasion was assessed on H&E stained slides and univariable and multivariable analyses were applied. Lymphatic invasion was detected in 95 (57%) cases and was significantly associated with tumour and node classification and tumour differentiation. Patients with tumours showing lymphatic invasion had decreased progression-free survival (p=0.025) and cancer-specific survival (p=0.082). Stratified by location, lymphatic invasion was significantly associated with decreased progression-free (p=0.010) and cancer-specific (p=0.023) survival in colon cancers, yet not in rectal cancers. Multivariable analysis proved T4 (HR 2.18, 95% CI 1.40 to 3.39; p<0.001) and N2 (HR 1.68, 95% CI 1.07 to 2.66; p=0.03) as independent predictors of progression-free survival and T4 (HR 1.90, 95% CI 1.17 to 3.07; p=0.009), N2 (HR 2.27, 95% CI 1.38 to 3.73; p=0.001) and poor tumour differentiation (HR 2.18, 95% CI 1.39 to 3.43; p<0.001) as independent predictors of cancer-specific survival, while for lymphatic invasion no influence on outcome was noted. In conclusion, only tumour and node classification, and tumour differentiation proved to be independent prognostic variables in node-positive colorectal cancer and merit special attention in clinical decision-making.
- Find related publications in this database (using NLM MeSH Indexing)
- Adenocarcinoma - mortality Adenocarcinoma - secondary Adenocarcinoma - therapy
- Adult -
- Aged -
- Aged, 80 and over -
- Biopsy -
- Cell Differentiation -
- Chi-Square Distribution -
- Colorectal Neoplasms - mortality Colorectal Neoplasms - pathology Colorectal Neoplasms - therapy
- Decision Support Techniques -
- Disease-Free Survival -
- Female -
- Humans -
- Kaplan-Meier Estimate -
- Lymph Nodes - pathology
- Lymphatic Metastasis -
- Male -
- Middle Aged -
- Multivariate Analysis -
- Neoplasm Invasiveness -
- Predictive Value of Tests -
- Prognosis -
- Proportional Hazards Models -
- Retrospective Studies -
- Risk Assessment -
- Risk Factors -
- Time Factors -