Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Kitzler, TM; Jaberi, A; Sendlhofer, G; Rehak, P; Binder, C; Petnehazy, E; Stacher, R; Kotanko, P.
Efficacy of vitamin E and N-acetylcysteine in the prevention of contrast induced kidney injury in patients with chronic kidney disease: a double blind, randomized controlled trial.
Wien Klin Wochenschr. 2012; 124(9-10):312-319
Doi: 10.1007/s00508-012-0169-2
Web of Science
PubMed
FullText
FullText_MUG
- Co-Autor*innen der Med Uni Graz
- Rehak Peter
- Sendlhofer Gerald
- Altmetrics:
- Dimensions Citations:
- Plum Analytics:
- Scite (citation analytics):
- Abstract:
- Contrast induced acute kidney injury is one of the most frequent causes of hospital acquired acute kidney injury. The present study aims to investigate the efficacy of vitamin E or N-acetylcysteine as an adjunct to current standard therapy in the prevention of this clinical predicament. We tested the hypothesis that vitamin E or N-acetylcysteine added to standard therapy with 0.45 % saline is superior in preserving renal function in patients with chronic kidney disease stage 1-4 undergoing elective computer-assisted tomography with nonionic radiocontrast agents when compared to 0.45 % saline alone. Prospective, randomized, single-center, double-masked, double dummy, placebo-controlled, parallel clinical trial. The patients were randomized to either vitamin E (total dose 2160 mg i.v.) or N-acetylcysteine (total dose 4800 mg p.o.) in addition to 0.45 % saline (1 mL/kg/h over 24 h) or saline alone. Serum creatinine change between baseline and 24 h after radiocontrast was the primary outcome. Contrast induced acute kidney injury was defined as a rise in serum creatinine > 25 % over the baseline value within 48 h. Thirty patients (mean age 74.6 years; 17 females; 9 diabetics; all Caucasians; mean serum creatinine 1.35 mg/dL; mean creatinine clearance 56 mL/min) were enrolled. No patient developed contrast induced acute kidney injury. There was no significant difference in serum creatinine change between the three study arms. Following radiocontrast administration, neither vitamin E nor N-acetylcystein in addition to saline demonstrated an additional beneficial effect on kidney function when compared to saline alone.
- Find related publications in this database (using NLM MeSH Indexing)
- Acetylcysteine - administration & dosage
- Acute Kidney Injury - chemically induced Acute Kidney Injury - diagnosis Acute Kidney Injury - prevention & control
- Aged -
- Contrast Media - adverse effects
- Double-Blind Method -
- Female -
- Free Radical Scavengers - administration & dosage
- Humans -
- Iohexol - adverse effects Iohexol - analogs & derivatives
- Kidney Failure, Chronic - complications Kidney Failure, Chronic - diagnosis Kidney Failure, Chronic - drug therapy
- Male -
- Treatment Outcome -
- Vitamin E - administration & dosage
- Find related publications in this database (Keywords)
- Computer-assisted tomography
- Contrast induced acute kidney injury
- N-acetylcysteine
- Randomized controlled trial
- Vitamin E
- Chronic kidney disease