Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
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Kamolz, LP; Lumenta, DB; Kitzinger, HB; Frey, M.
Tissue engineering for cutaneous wounds: an overview of current standards and possibilities
EUR SURG. 2008; 40(1): 19-26.
Doi: 10.1007/s10353-008-0380-6
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- Führende Autor*innen der Med Uni Graz
- Kamolz Lars-Peter
- Co-Autor*innen der Med Uni Graz
- Lumenta David Benjamin
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- Abstract:
- Background: The skin is the largest organ system in humans, consisting of various distinctive layers, each stratum with a specific purpose. Consequently, our skin incorporates the most essential function, which is to protect our body. Loss of skin integrity because of injury or illness may acutely result in a substantial physiologic imbalance and ultimately in a disability with long-term morbidity or even death. Methods: This article is an overview of current state-of-the-art concepts and possibilities in the treatment of cutaneous wounds by the use of tissue engineering. Results: The most common cause of significant skin loss is thermal injury. Other causes of skin loss include trauma and chronic ulcerations secondary to diabetes mellitus, pressure, and venous stasis. Over the past three decades, extraordinary advances have been made in our understanding of the cellular and molecular processes involved in acute wound healing and in the pathobiology of chronic wounds. Conclusions: This knowledge has led to wound care innovations that have facilitated more rapid closure of chronic and acute wounds, better functional and aesthetic outcome. The use of tissue-engineered skin replacements has upgraded the therapeutic possibilities for recalcitrant wounds and for wounds that are not suitable for primary closure.
- Find related publications in this database (Keywords)
- tissue engineering
- epidermal replacements
- dermal matrix
- dermal replacements
- keratinocytes