Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
Zausinger, S; Lumenta, DB; Pruneau, D; Schmid-Elsaesser, R; Plesnila, N; Baethmann, A.
Therapeutical efficacy of a novel non-peptide bradykinin B2 receptor antagonist on brain edema formation and ischemic tissue damage in focal cerebral ischemia.
Acta Neurochir Suppl. 2003; 86:205-207
Doi: 10.1007/978-3-7091-0651-8_44
PubMed
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- Co-Autor*innen der Med Uni Graz
- Lumenta David Benjamin
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- Abstract:
- OBJECTIVE: Bradykinin has been identified as a mediator of secondary brain damage in acute insults. We currently studied neuroprotective properties of a bradykinin B2 receptor antagonist (LF16-0687 Ms) in transitory focal cerebral ischemia to assess infarct formation and the development of brain edema. MATERIAL AND METHODS: 55 Rats were subjected to 90 min of MCA-occlusion. The receptor antagonist was administered at two dose levels, given from 30 min prior to ischemia over two days after ischemia. Ischemic tissue damage was quantified at day 7 after MCA-occlusion together with assessment of brain edema in separate experiments. Neurological recovery was studied daily. RESULTS: Animals receiving treatment (low dose) had a better functional recovery, particularly at days 3 and 4 (P < 0.05). Infarct formation was significantly attenuated in these animals in both total and cortical brain tissue by 50, or 80%, respectively. Postischemic brain swelling was significantly lowered, i.e. by 62%. CONCLUSIONS: Our findings provide further support for a mediator role of bradykinin in ischemic brain damage including edema formation, obviously by ligand binding to the bradykinin B2 receptor. The availability of a receptor antagonist may afford opportunity for translation of this experimental treatment into stroke patients.
- Find related publications in this database (using NLM MeSH Indexing)
- Animals -
- Brain - pathology
- Brain Edema - etiology
- Brain Ischemia - complications Brain Ischemia - pathology Brain Ischemia - physiopathology
- Cerebral Infarction - pathology Cerebral Infarction - prevention and control
- Male -
- Nervous System - drug effects Nervous System - physiopathology
- Organ Size - drug effects
- Quinolines - pharmacology
- Rats -
- Rats, Sprague-Dawley -
- Receptor, Bradykinin B2 - antagonists and inhibitors