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Kerl, K; Kempf, W; Kamarashev, J; Spallone, G; Braun, R; Wiesner, T; French, LE; Dummer, R.
Constitutional intraepidermal ascent of melanocytes: a potential pitfall in the diagnosis of melanocytic lesions.
Arch Dermatol. 2012; 148(2):235-238 Doi: 10.1001/archdermatol.2011.2026 (- Case Report) [OPEN ACCESS]
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Co-authors Med Uni Graz: Wiesner Thomas
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Abstract:: Transepidermal melanocytic migration (TEM) is an important diagnostic criterion for malignancy, especially in association with cytologic atypia. However, TEM may also be observed in benign melanocytic tumors, such as Spitz nevus, acral nevi, or nevi in infancy. We discuss the value of TEM for the diagnosis of melanocytic tumors in a young patient previously diagnosed as having 11 cutaneous melanomas. A 17-year-old patient with a history of 11 cutaneous melanomas diagnosed in the past 3 years by different expert dermatopathologists presented in our department. The previous histological diagnoses of melanoma were mainly based on the presence of important TEM. A reevaluation of all histological specimens in light of the clinical context and the lack of genomic aberrations as detected by array-comparative genomic hybridization led to a revision of the previous diagnoses. The striking TEM observed represents, in our opinion, a constitutional element of the melanocytic nevi in this patient and not a marker of malignancy. Awareness of this finding is important to avoid overdiagnosis of melanoma in cases of melanocytic nevi.
Find related publications in this database (using NLM MeSH Indexing): Adolescent -; Cell Movement -; DNA Copy Number Variations -; Dermoscopy -; Female -; Humans -; Melanocytes - pathology; Melanoma - diagnosis Melanoma - genetics Melanoma - pathology; Microscopy, Confocal -; Skin Diseases - diagnosis Skin Diseases - genetics Skin Diseases - pathology