Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Pattaro, C; Köttgen, A; Teumer, A; Garnaas, M; Böger, CA; Fuchsberger, C; Olden, M; Chen, MH; Tin, A; Taliun, D; Li, M; Gao, X; Gorski, M; Yang, Q; Hundertmark, C; Foster, MC; O'Seaghdha, CM; Glazer, N; Isaacs, A; Liu, CT; Smith, AV; O'Connell, JR; Struchalin, M; Tanaka, T; Li, G; Johnson, AD; Gierman, HJ; Feitosa, M; Hwang, SJ; Atkinson, EJ; Lohman, K; Cornelis, MC; Johansson, Å; Tönjes, A; Dehghan, A; Chouraki, V; Holliday, EG; Sorice, R; Kutalik, Z; Lehtimäki, T; Esko, T; Deshmukh, H; Ulivi, S; Chu, AY; Murgia, F; Trompet, S; Imboden, M; Kollerits, B; Pistis, G; CARDIoGRAM Consortium; ICBP Consortium; CARe Consortium; Wellcome Trust Case Control Consortium 2 (WTCCC2); Harris, TB; Launer, LJ; Aspelund, T; Eiriksdottir, G; Mitchell, BD; Boerwinkle, E; Schmidt, H; Cavalieri, M; Rao, M; Hu, FB; Demirkan, A; Oostra, BA; de Andrade, M; Turner, ST; Ding, J; Andrews, JS; Freedman, BI; Koenig, W; Illig, T; Döring, A; Wichmann, HE; Kolcic, I; Zemunik, T; Boban, M; Minelli, C; Wheeler, HE; Igl, W; Zaboli, G; Wild, SH; Wright, AF; Campbell, H; Ellinghaus, D; Nöthlings, U; Jacobs, G; Biffar, R; Endlich, K; Ernst, F; Homuth, G; Kroemer, HK; Nauck, M; Stracke, S; Völker, U; Völzke, H; Kovacs, P; Stumvoll, M; Mägi, R; Hofman, A; Uitterlinden, AG; Rivadeneira, F; Aulchenko, YS; Polasek, O; Hastie, N; Vitart, V; Helmer, C; Wang, JJ; Ruggiero, D; Bergmann, S; Kähönen, M; Viikari, J; Nikopensius, T; Province, M; Ketkar, S; Colhoun, H; Doney, A; Robino, A; Giulianini, F; Krämer, BK; Portas, L; Ford, I; Buckley, BM; Adam, M; Thun, GA; Paulweber, B; Haun, M; Sala, C; Metzger, M; Mitchell, P; Ciullo, M; Kim, SK; Vollenweider, P; Raitakari, O; Metspalu, A; Palmer, C; Gasparini, P; Pirastu, M; Jukema, JW; Probst-Hensch, NM; Kronenberg, F; Toniolo, D; Gudnason, V; Shuldiner, AR; Coresh, J; Schmidt, R; Ferrucci, L; Siscovick, DS; van Duijn, CM; Borecki, I; Kardia, SL; Liu, Y; Curhan, GC; Rudan, I; Gyllensten, U; Wilson, JF; Franke, A; Pramstaller, PP; Rettig, R; Prokopenko, I; Witteman, JC; Hayward, C; Ridker, P; Parsa, A; Bochud, M; Heid, IM; Goessling, W; Chasman, DI; Kao, WH; Fox, CS.
Genome-wide association and functional follow-up reveals new loci for kidney function.
PLoS Genet. 2012; 8(3):e1002584-e1002584
Doi: 10.1371/journal.pgen.1002584
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- Co-Autor*innen der Med Uni Graz
- Cavalieri Margherita
- Schmidt Helena
- Schmidt Reinhold
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- Abstract:
- Chronic kidney disease (CKD) is an important public health problem with a genetic component. We performed genome-wide association studies in up to 130,600 European ancestry participants overall, and stratified for key CKD risk factors. We uncovered 6 new loci in association with estimated glomerular filtration rate (eGFR), the primary clinical measure of CKD, in or near MPPED2, DDX1, SLC47A1, CDK12, CASP9, and INO80. Morpholino knockdown of mpped2 and casp9 in zebrafish embryos revealed podocyte and tubular abnormalities with altered dextran clearance, suggesting a role for these genes in renal function. By providing new insights into genes that regulate renal function, these results could further our understanding of the pathogenesis of CKD.
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