Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Pichler, M; Hutterer, GC; Chromecki, TF; Jesche, J; Kampel-Kettner, K; Pummer, K; Zigeuner, R.
Renal cell carcinoma stage migration in a single European centre over 25 years: effects on 5- and 10-year metastasis-free survival.
Int Urol Nephrol. 2012; 44(4):997-1004
Doi: 10.1007/s11255-012-0165-5
Web of Science
PubMed
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- Führende Autor*innen der Med Uni Graz
- Hutterer Georg
- Pichler Martin
- Co-Autor*innen der Med Uni Graz
- Chromecki Thomas
- Jesche-Chromecki Johanna
- Pummer Karl
- Strini Karin
- Zigeuner Richard
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- Abstract:
- To assess renal cell carcinoma (RCC) stage migration in a large European academic centre series over 25 years and its possible impact on patients' metastasis-free survival. The pathology reports of 2,333 consecutive patients with RCC who underwent nephrectomy from 1984 to 2006 at our institution were systematically re-evaluated. Patients were pooled into four groups according to the date of surgery: group 1: 1984-1989, group 2: 1990-1995, group 3: 1996-2001 and group 4: 2002-2006, respectively. Changes in pT-categories over time and the impact on 5- and 10-year metastasis-free survival were evaluated. Organ-confined (pT1 and pT2) tumours were found in 191/502 (38.0 %) and 372/535 (69.5 %) surgical specimens in groups 1 and 4, respectively (p < 0.001). This stage migration was mainly the result of an increase in pT1a tumours (overall: 32.6 %) from 12.5 % in group 1 to 45.8 % in group 4 and a decrease in pT3a tumours (overall: 24.1 %) from 46.6 % in group 1 to 11.0 % in group 4 (p < 0.001). The mean tumour size decreased from 6.7 cm in group 1 to 4.8 cm in group 4 (p < 0.001). In 2,152 patients with non-metastatic RCC, median follow-up was 76.2 (interquartile range: 36.2-133.9) months. Five- and 10-year metastasis-free survival probabilities were 78.7 and 71.9 % in group 1, 85.3 and 80.0 % in group 2, and 86.9 and 82.7 % in group 3, respectively. Five-year metastasis-free survival in group 4 was 90.3 % (p < 0.001). A statistically significant stage migration towards organ-confined RCC was observed in the cohort studied. This stage migration was accompanied by a significant improvement in metastasis-free survival comparing the period 1984-1989 and following time periods.
- Find related publications in this database (using NLM MeSH Indexing)
- - epidemiology
- Carcinoma, Renal Cell - diagnosis
- Disease-Free Survival -
- Female -
- Follow-Up Studies -
- Humans -
- Kidney Neoplasms - epidemiology
- Male -
- Middle Aged -
- Neoplasm Staging -
- Prognosis -
- Retrospective Studies -
- Time Factors -
- Find related publications in this database (Keywords)
- Caucasian population
- Metastasis-free survival
- Renal cell carcinoma
- Stage migration