Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Einspieler, C; Marschik, PB.
Central Pattern Generators and Their Significance for the Foetal Motor Function
KLIN NEUROPHYSIOL. 2012; 43(1): 16-21.
Doi: 10.1055/s-0031-1286264
Web of Science
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- Führende Autor*innen der Med Uni Graz
- Einspieler Christa
- Co-Autor*innen der Med Uni Graz
- Marschik Peter
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- Abstract:
- Although evidence for the existence of endogenously generated motor activity goes back to experiments conducted more than a century ago, a lot remains to be learnt about the fascinating network that is the central pattern generator (CPG). CPGs are neuronal circuits that can produce rhythmic motor patterns in the absence of oscillatory input. Some CPGs operate continuously (e. g., breathing movements); others are activated to perform specific behavioural tasks (e. g., locomotion). In order to lend flexibility to the motor output, supraspinal projections activate, inhibit, and, most of all, modulate the CPG activity, as does the sensory feedback. Embryonic and foetal motor patterns have all the characteristics of being endogenously generated. At no other stage of development is the neural structure so closely related to its own function. It only takes a few neurons to generate basic movements, which are, in turn, necessary for further development of the structure. Apart from the general interest in the evolution of early motor activity, the observation and assessment of spontaneous foetal and neonatal motility has also clinical implications, since a reduced CPG modulation results in less variable movements and indicates foetal or neonatal compromise.
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