Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Barral, S; Fernández-Cadenas, I; Bis, JC; Montaner, J; Ikram, AM; Launer, LJ; Fornage, M; Schmidt, H; Brickman, AM; Seshadri, S; Mayeux, R.
No association of ALOX5AP polymorphisms with risk of MRI-defined brain infarcts.
Neurobiol Aging. 2012; 33(3):629.e1-629.e3
Doi: 10.1016/j.neurobiolaging.2011.10.010
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- Co-Autor*innen der Med Uni Graz
- Schmidt Helena
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- Abstract:
- The arachidonate 5-lipoxygenase-activating protein (ALOX5AP) gene has been associated with stroke. The majority of the reported ALOX5AP associations have considered non-radiologically confirmed infarcts as the stroke phenotype. We assessed the association of genetic variants in ALOX5AP with stroke defined by the presence of infarcts on brain magnetic resonance imaging (MRI). We studied 202 persons with MRI-defined brain infarcts and 487 healthy individuals of Caribbean Hispanic ancestry. Another sample of European ancestry comprised 1823 persons with MRI-defined brain infarct and 7578 control subjects. Subjects were genotyped for the 4 single nucleotide polymorphisms (SNPs) that define ALOX5AP HapA haplotype. No association was found between SNPs and MRI-defined brain infarcts. Our data do not support the hypothesis that variants in ALOX5AP are associated with risk of MRI-defined brain infarcts. Copyright © 2012 Elsevier Inc. All rights reserved.
- Find related publications in this database (using NLM MeSH Indexing)
- 5-Lipoxygenase-Activating Proteins - genetics
- Brain Infarction - ethnology
- Brain Infarction - genetics
- Brain Infarction - pathology
- Brain Infarction - ethnology
- Case-Control Studies -
- Cohort Studies -
- Genetic Association Studies -
- Haplotypes - genetics
- Hispanic Americans - ethnology
- Hispanic Americans - genetics
- Humans -
- Magnetic Resonance Imaging -
- Polymorphism, Single Nucleotide - genetics
- Prospective Studies -
- Find related publications in this database (Keywords)
- MRI-defined brain infarcts
- ALOX5AP