Medizinische Universität Graz - Research portal
Selected Publication:
Walzl, M; Walzl, B; Kleinert, G; Schied, G; Lechner, H.
Heparin-induced extracorporeal LDL precipitation (HELP). A new therapeutic possibility in cerebral multi-infarct dementia
NERVENARZT. 1993; 64(10): 648-652.
Web of Science
PubMed
- Co-authors Med Uni Graz
- Kleinert Gertrude
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- Abstract:
- High fibrinogen levels have been assessed in cerebrovascular disease with a direct relationship to blood rheology. Heparin-induced extracorporeal LDL precipitation (HELP) is a method that effectively reduces fibrinogen and lipoproteins at the same time, thus improving the hemorheologic pattern. We studied 45 patients with cerebral multiinfarct dementia. After computer-randomization 30 patients received a HELP treatment, while the remaining 15 patients served as controls. HELP produced an immediate and statistically significant reduction on parameters relevant to hemorheology, such as fibrinogen (P < 0.001), total cholesterol, low-density lipoprotein, triglycerides (P < 0.0001 each) and whole blood viscosity (at high and low shear rate) as well as plasma viscosity and red cell transit time (P < 0.01 each). The treated group showed improvement after HELP (P < 0.05 for each test) on the Mathew Neurological Scale, Mini Mental State Examination and Activities-of-Daily-Living Test and also relative to the untreated controls (P < 0.05 each). These results may be regarded as a basis for some reflections about new hemorheological interventions in cases of cerebral multiinfarct dementia.
- Find related publications in this database (using NLM MeSH Indexing)
- Activities of Daily Living - psychology
- Aged - psychology
- Blood Component Removal - instrumentation
- Blood Viscosity - physiology
- Cholesterol - blood
- Dementia, Multi-Infarct - blood
- Erythrocyte Deformability - physiology
- Female - physiology
- Fibrinogen - metabolism
- Hemofiltration - instrumentation
- Heparin - administration and dosage
- Humans - administration and dosage
- Lipoproteins, LDL - blood
- Male - blood
- Mental Status Schedule - blood
- Middle Aged - blood
- Precipitation - blood
- Triglycerides - blood
- Find related publications in this database (Keywords)
- Help
- Viscosity
- Fibrinogen
- LDL
- Cholesterol
- Rctt