Medizinische Universität Graz - Research portal
Selected Publication:
SHR Neuro Cancer Cardio Lipid Metab Microb
Heitzeneder, S; Seidel, M; Förster-Waldl, E; Heitger, A.
Mannan-binding lectin deficiency - Good news, bad news, doesn't matter?
Clin Immunol. 2012; 143(1): 22-38.
Doi: 10.1016/j.clim.2011.11.002
Web of Science
PubMed
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- Co-authors Med Uni Graz
- Seidel Markus
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- Abstract:
- Mannan-binding lectin (MBL) deficiency has been classified as a commonly occurring immune disorder, affecting approximately 30% of the human population. MBL, being part of the innate immune system, supports the recognition of infectious pathogens by binding to carbohydrate moieties expressed on microorganisms and activates the lectin pathway of the complement system. MBL2 gene polymorphisms are associated with quantitative and qualitative MBL abnormalities in the serum. The clinical impact of MBL deficiency and its association to a wide variety of diseases has been extensively studied. The picture is puzzling as the studies suggest a detrimental or beneficial or no impact of low or high MBL serum levels on disease susceptibility. In this review we attempt to extract what is relevant from the literature and address controversial issues. We finally suggest that a comprehensive understanding of the role of MBL in human diseases requires considering its context-dependency.
Copyright é 2011 Elsevier Inc. All rights reserved. - Find related publications in this database (using NLM MeSH Indexing)
- Genetic Predisposition to Disease -
- Genotype -
- Humans -
- Mannose-Binding Lectin - blood
- Models, Genetic -
- Polymorphism, Single Nucleotide -
- Find related publications in this database (Keywords)
- Mannan-binding lectin
- Innate immunity
- Pattern recognition molecules
- Lectin pathway of complement
- Immunodeficiency
- Disease association