Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Schmied, MC; Zehetmayer, S; Reindl, M; Ehling, R; Bajer-Kornek, B; Leutmezer, F; Zebenholzer, K; Hotzy, C; Lichtner, P; Meitinger, T; Wichmann, HE; Illig, T; Gieger, C; Huber, K; Khalil, M; Fuchs, S; Schmidt, H; Auff, E; Kristoferitsch, W; Fazekas, F; Berger, T; Vass, K; Zimprich, A.
Replication study of multiple sclerosis (MS) susceptibility alleles and correlation of DNA-variants with disease features in a cohort of Austrian MS patients.
Neurogenetics. 2012; 13(2):181-187
Doi: 10.1007/s10048-012-0316-y
Web of Science
PubMed
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- Co-Autor*innen der Med Uni Graz
- Fazekas Franz
- Fuchs Siegrid
- Khalil Michael
- Schmidt Helena
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- Abstract:
- We performed a replication study in 883 Austrian multiple sclerosis (MS) patients and 972 control individuals for 25 previously risk-associated loci (39 SNPs). Two loci, rs1109670 (DDEF2/MBOAT2, p < 0.02) and rs16914086 (TBC1D2, p < 0.05), are replicated here for the first time. Furthermore, we tested all 39 SNPs for association with age at disease onset and measures of disease severity. We observed a trend for association of rs3135388 (HLA-DRB1*1501, p < 0.01), rs7090530 (IL2RA, p < 0.026) and rs1841770 (ZIC1, p < 0.017) with a younger age at MS onset and of rs12044852 (CD58, p < 0.035) with shorter time to reach EDSS6.
- Find related publications in this database (using NLM MeSH Indexing)
- Adult -
- Age of Onset -
- Aged -
- Alleles -
- Alleles -
- Cohort Studies -
- DNA - genetics
- DNA Replication -
- Female -
- Gene Frequency - genetics
- Genetic Predisposition to Disease -
- Genotype -
- Humans -
- Male -
- Middle Aged -
- Multiple Sclerosis - genetics
- Polymorphism, Single Nucleotide -
- Severity of Illness Index -
- Find related publications in this database (Keywords)
- Multiple sclerosis
- Risk genes
- Replication study