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Evangelista, S; Renzi, D; Lippe, IT; Mantellini, P; Guzzi, P; Maggi, CA.
Intraluminal release of PGE2 due to gastric perfusion of urethane-anaesthetized rats with hydrochloric or taurocholic acid.
INT J TISSUE REACT. 1990; 12(4): 237-241.
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Co-authors Med Uni Graz: Lippe Irmgard Theresia
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Abstract:: We have measured the intragastric release of prostaglandin E2-like immunoreactivity (PGE2-li), pH changes and mucosal damage in response to gastric perfusion with hydrochloric or taurocholic acid at pH 1.5 in urethane-anaesthetized rats. Hydrochloric acid-perfusion caused a reversible decrease in pH values, no damage to the gastric mucosa and an intraluminal release of PGE2-li. Exposure to an ulcerogenic dose (25 mM) of taurocholic acid produced an intraluminal release of PGE2-li much higher than that of the non-ulcerogenic perfusion with hydrochloric acid. These findings indicate that intraluminal release of PGE2-li, thought to play a role as an endogenous antiulcer factor, can occur in response to a stimulus producing a significant damage of the gastric mucosa or to a mild irritant stimulus.
Find related publications in this database (using NLM MeSH Indexing): Anesthesia -; Animals -; Dinoprostone - metabolism; Hydrochloric Acid - administration and dosage; Hydrogen-Ion Concentration - administration and dosage; Immunoenzyme Techniques - administration and dosage; Male - administration and dosage; Perfusion - administration and dosage; Rats - administration and dosage; Rats, Inbred Strains - administration and dosage; Stomach - metabolism; Stomach Ulcer - chemically induced; Taurocholic Acid - administration and dosage; Time Factors - administration and dosage; Urethane - administration and dosage