Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Goswami, N; Roessler, A; Hinghofer-Szalkay, H; Montani, JP; Steptoe, A.
Delaying orthostatic syncope with mental challenge: A pilot study.
Physiol Behav. 2012; 106(4):569-573
Doi: 10.1016/j.physbeh.2012.02.022
Web of Science
PubMed
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FullText_MUG
- Führende Autor*innen der Med Uni Graz
- Goswami Nandu
- Co-Autor*innen der Med Uni Graz
- Hinghofer-Szalkay Helmut
- Rössler Andreas
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- Abstract:
- At orthostatic vasovagal syncope there appears to be a sudden decline of sympathetic activity. As mental challenge activates the sympathetic system, we hypothesized that doing mental arithmetic in volunteers driven to the end point of their cardiovascular stability may delay the onset of orthostatic syncope. We investigated this in healthy male subjects. Each subject underwent a head up tilt (HUT)+ graded lower body negative pressure (LBNP) up to presyncope session (control) to determine the orthostatic tolerance time, OTT (Time from HUT commencement to development of presyncopal symptoms/signs). Once the tolerance time was known, a randomized crossover protocol was used: either 1) Repeat HUT+LBNP to ensure reproducibility of repeated run or 2) HUT+LBNP run but with added mental challenge (2 min before the expected presyncope time). Test protocols were separated by 2 weeks. Our studies on five male test subjects indicate that mental challenge improves orthostatic tolerance significantly. Additional mental loading could be a useful countermeasure to alleviate the orthostatic responses of persons, particularly in those with histories of dizziness on standing up, or to alleviate hypotension that frequently occurs during hemodialysis or on return to earth from the spaceflight environment of microgravity.
- Find related publications in this database (using NLM MeSH Indexing)
- Adult -
- Cross-Over Studies -
- Electrocardiography -
- Hemodynamics -
- Humans -
- Hypotension, Orthostatic - prevention & control
- Lower Body Negative Pressure -
- Male -
- Mathematics -
- Mental Processes - physiology
- Pilot Projects -
- Space Flight -
- Syncope - prevention & control
- Tilt-Table Test -
- Vascular Resistance -
- Find related publications in this database (Keywords)
- Head up tilt
- Lower body negative pressure
- Vasovagal syncope
- Mental arithmetic
- Blood pressure