Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Gattringer, T; Enzinger, C; Ropele, S; Gorani, F; Petrovic, KE; Schmidt, R; Fazekas, F.
Vascular risk factors, white matter hyperintensities and hippocampal volume in normal elderly individuals.
Dement Geriatr Cogn Disord. 2012; 33(1):29-34
Doi: 10.1159/000336052
Web of Science
PubMed
FullText
FullText_MUG
- Führende Autor*innen der Med Uni Graz
- Enzinger Christian
- Gattringer Thomas
- Co-Autor*innen der Med Uni Graz
- Fazekas Franz
- Gorani Faton
- Petrovic Katja-Elisabeth
- Ropele Stefan
- Schmidt Reinhold
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- Abstract:
- Background/Aims: Hippocampal atrophy has been identified as marker for the development of Alzheimer's dementia (AD). To what extent vascular risk factors and white matter hyperintensities (WMH) affect hippocampal volume (HV) in asymptomatic elderly subjects and thus may impact such a predictive capacity is controversial. Methods: We analysed 287 participants of the Austrian Stroke Prevention Study (mean age 66.6 +/- 6.6 years) with a Mini Mental State Examination score >= 27 who were free of neuropsychiatric disease and had undergone MRI including coronal T-1-weighted sequences allowing for semi-automatic assessment of HV. Global brain volume (BV) was measured using SIENAX. WMH were rated according to the Fazekas scale and segmented to obtain WMH volumes. Results: Higher age was associated with lower absolute and normalized HV, a lower BV and higher WMH volume. None of the vascular risk factors had an impact on HV except for high-density lipoprotein. This effect disappeared after normalization of HV. WMH severity and volume did not affect HV either. Conclusion: Our data indicate HV loss in parallel with the whole brain and suggest no specific vulnerability towards vascular risk factors or age-related WMH in a cognitively intact normal elderly population. This also supports the utility of HV measurements to identify impending AD. Copyright (C) 2012 S. Karger AG, Basel
- Find related publications in this database (using NLM MeSH Indexing)
- Age Factors -
- Aged -
- Aged, 80 and over -
- Aging - physiology
- Anatomy, Cross-Sectional -
- Atrophy -
- Atrophy -
- Brain - growth and development Brain - pathology
- Cerebral Small Vessel Diseases - epidemiology Cerebral Small Vessel Diseases - pathology
- Cohort Studies -
- Data Interpretation, Statistical -
- Female -
- Hippocampus - pathology
- Humans -
- Image Processing, Computer-Assisted -
- Leukoencephalopathies - epidemiology Leukoencephalopathies - pathology
- Magnetic Resonance Imaging -
- Male -
- Middle Aged -
- Reference Values -
- Risk Factors -
- Vascular Diseases - epidemiology
- Find related publications in this database (Keywords)
- Normal ageing
- Magnetic resonance imaging
- Hippocampal volume
- White matter hyperintensities
- White matter changes
- Vascular risk factors