Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
Walzl, M; Lechner, H; Walzl, B; Kleinert, G; Schied, G; Freidl, W; Bertha, G.
Hemorrheology and quality of life in fibrinogen- and lipid-lowering therapy
SCHWEIZ MED WOCHENSCHR. 1993; 123: 1875-1882.
Web of Science
PubMed
- Co-Autor*innen der Med Uni Graz
- Bertha Goetz
- Freidl Wolfgang
- Kleinert Gertrude
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- Abstract:
- Previous studies have demonstrated that heparin-induced extracorporeal LDL precipitation is able to reduce total cholesterol, LDL, triglycerides and plasma fibrinogen at the same time and thus improve the hemorheologic pattern. A combination of H.E.L.P. and bezafibrate, which also has a lipid- and fibrinogen-lowering potency, was applied in patients suffering from cerebral multi-infarct dementia and disturbances of the hemorheologic situation. In view of observations regarding improved quality of life after H.E.L.P., a prospective, randomized trial was conducted to determine possible interactions between improved hemorheology and better quality of life. To obtain a low baseline of laboratory parameters, all the patients underwent a single H.E.L.P. session and were then (double-blind) stratified into 2 groups: group 1 (16 males, 5 females, age 67.9 +/- 6.8 years) received sustained-release bezafibrate 400 mg (Bezalip) per day, while group 2 served as controls, and comprised 14 males and 5 females (age 69.2 +/- 6.8 years) who received placebo for a period of 56 days. After H.E.L.P. a statistically significant reduction of the following parameters relevant to hemorheology was obtained: fibrinogen (p < 0.0001), whole blood viscosity (low shear rate p < 0.007 and high shear rate p < 0.005), plasma viscosity (p < 0.002) and red cell transit time (p < 0.0001). Also, the metabolic parameters were influenced positively (p < 0.0001 for total cholesterol, LDL and triglycerides).(ABSTRACT TRUNCATED AT 250 WORDS)
- Find related publications in this database (using NLM MeSH Indexing)
- Aged -
- Bezafibrate - administration and dosage
- Blood Viscosity - administration and dosage
- Dementia, Multi-Infarct - blood
- Double-Blind Method - blood
- English Abstract - blood
- Female - blood
- Fibrinogen - metabolism
- Hemofiltration - methods
- Heparin - therapeutic use
- Humans - therapeutic use
- Lipids - blood
- Lipoproteins, LDL Cholesterol - blood
- Male - blood
- Mental Status Schedule - blood
- Quality of Life - blood