Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
Zöchbauer, S; Schwarzinger, I; Strobl, H; Lechner, K; Pirker, R.
Relationship between MDR1 gene and surface markers in acute myeloid leukemia.
Anticancer Res. 1997; 17(1B):749-752
Web of Science
PubMed
Google Scholar
- Co-Autor*innen der Med Uni Graz
- Strobl Herbert
- Altmetrics:
- Dimensions Citations:
- Plum Analytics:
- Abstract:
- The MDR1 gene is of prognostic significance in acute myeloid leukemia (AML). The relationship of this gene to surface markers largely remains unclear. Therefore, we have studied the association of MDR1 gene expression with the expression of specific surface markers in AML. MDR1 RNA expression of leukemic cells was determined by slot blot analysis. Expression of P-glycoprotein and surface markers (CD7, CD13, CD19, CD34, HLA-DR, TdT, blood group H) was assessed by immunocytochemistry. MDR1 RNA (n = 79) and P-glycoprotein (n = 52) expression were detected in 63% and 63% of the patients, respectively. CD7, CD13, CD19, CD34, HLA-DR, TdT and blood group H were positive in 17%, 84%, 0%, 51%, 82%, 11% and 11% of the patients. MDR1 RNA or P-glycoprotein expression were not associated with the expression of either CD7, CD13, CD19, CD34, TdT or blood group H. However, P-glycoprotein expression was more frequent in HLA-DR positive than in HLA-DR negative patients (47% versus 10%, p = 0,04). Consistent with the latter finding, patients with intermediate or high MDR1 RNA expression expressed HLA-DR more frequently than patients with negative or weak MDR1 RNA expression (96% versus 76%, p = 0,03). In conclusion, MDR1 gene expression of AML cells was independent of surface markers except HLA-DR.
- Find related publications in this database (using NLM MeSH Indexing)
- Acute Disease -
- Antigens, Neoplasm - metabolism
- Antigens, Surface - metabolism
- Female -
- Gene Expression Regulation, Leukemic -
- Genes, MDR - physiology
- Humans -
- Leukemia, Myeloid - immunology Leukemia, Myeloid - metabolism
- Male -
- P-Glycoprotein - genetics P-Glycoprotein - metabolism
- RNA, Messenger - metabolism
- Find related publications in this database (Keywords)
- MDR1 gene
- P-glycoprotein
- surface markers
- acute myeloid leukemia
- phenotyping