Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
Strobl, H; Knapp, W.
TGF-beta1 regulation of dendritic cells.
Microbes Infect. 1999; 1(15):1283-1290
Doi: 10.1016/S1286-4579(99)00256-7
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- Führende Autor*innen der Med Uni Graz
- Strobl Herbert
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- Abstract:
- Dendritic cells (DCs) represent antigen-presenting cell (APC) populations in lymphoid and nonlymphoid organs which are considered to play key roles in the initiation of antigen-specific T-cell proliferation. According to current knowledge, the net outcome of T-cell immune responses seems to be significantly influenced by the activation stage of antigen-presenting DCs. Several studies have shown that transforming growth factor-beta 1 (TGF-beta1) inhibits in vitro activation and maturation of DCs. TGF-beta1 inhibits upregulation of critical T-cell costimulatory molecules on the surface of DCs and reduces the antigen-presenting capacity of DCs. Thus, in addition to direct inhibitory effects of TGF-beta1 on effector T lymphocytes, inhibitory effects of TGF-beta1 at the level of APCs may critically contribute to previously characterized immunosuppressive effects of TGF-beta1. In contrast to these negative regulatory effects of TGF-beta1 on function and maturation of lymphoid tissue type DCs, certain subpopulations of immature DCs in nonlymphoid tissues are positively regulated by TGF-beta1 signaling. In particular, epithelial-associated DC populations seem to critically require TGF-beta1 stimulation for development and function. Recent studies established that TGF-beta1 stimulation is absolutely required for the development of epithelial Langerhans cells (LCs) in vitro and in vivo. Furthermore, TGF-beta1 seems to enhance antigen processing and costimulatory functions of epithelial LCs.
- Find related publications in this database (using NLM MeSH Indexing)
- Animals -
- Antigen Presentation - physiology
- Dendritic Cells - metabolism
- Humans -
- T-Lymphocytes - physiology
- Transforming Growth Factor beta - physiology
- Find related publications in this database (Keywords)
- TGF-beta
- dendritic cell
- Langerhans cell
- differentiation
- antigen presentation