Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
Strobl, H.
Molecular mechanisms of dendritic cell sublineage development from human hematopoietic progenitor/stem cells.
Int Arch Allergy Immunol. 2003; 131(2):73-79
Doi: 10.1159/000070921
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- Führende Autor*innen der Med Uni Graz
- Strobl Herbert
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- Abstract:
- In vitro differentiation models of human CD34+ hematopoietic progenitor/stem cells have contributed significantly to our current understanding of dendritic cell (DC) development. DC sublineages seem to arise from common progenitors with monocytic cells. These progenitors seem to respond to instructive signals from cytokine receptors and steroids to follow defined sublineage differentiation pathways. Transcriptional processes involved in the regulation of lineage fate decisions of putative common DC progenitors remain poorly defined, as is our knowledge of the identities of DC precursors in vivo. Most likely, tissue-specific microenvironmental signals, including tumor-derived signals, critically modulate DC phenotype and function in vivo.
- Find related publications in this database (using NLM MeSH Indexing)
- Animals -
- Antigens, CD34 - immunology
- Calcitriol - immunology Calcitriol - physiology
- Dendritic Cells - immunology Dendritic Cells - physiology
- Granulocyte-Macrophage Colony-Stimulating Factor - immunology
- Hematopoiesis - immunology Hematopoiesis - physiology
- Hematopoietic Stem Cells - immunology Hematopoietic Stem Cells - physiology
- Humans -
- Langerhans Cells - immunology Langerhans Cells - physiology
- Membrane Proteins -
- Models, Animal -
- Myelopoiesis - immunology Myelopoiesis - physiology
- Receptors, Notch -
- Signal Transduction - immunology Signal Transduction - physiology
- Transforming Growth Factors - immunology
- Tumor Cells, Cultured -
- Tumor Necrosis Factor-alpha - immunology
- Find related publications in this database (Keywords)
- dendritic cells
- hematopoiesis
- CD34+cells
- Langerhans cells
- myelopoiesis